{"id":136407,"date":"2022-03-04T00:22:18","date_gmt":"2022-03-04T08:22:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/03\/targeting-the-cell-cycle-could-overcome-cancer-treatment-resistance"},"modified":"2022-03-04T00:22:18","modified_gmt":"2022-03-04T08:22:18","slug":"targeting-the-cell-cycle-could-overcome-cancer-treatment-resistance","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/03\/targeting-the-cell-cycle-could-overcome-cancer-treatment-resistance","title":{"rendered":"Targeting the cell cycle could overcome cancer treatment resistance"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/targeting-the-cell-cycle-could-overcome-cancer-treatment-resistance2.jpg\"><\/a><\/p>\n<p>Scientists from Roswell Park Comprehensive Cancer Center have shed light on a different way of overcoming mechanisms of resistance to specific therapeutic agents used to treat cancer. In a new article published March 1 in the journal <i>Cell Reports<\/i>, the researchers propose a new approach to cancer treatment based on the way different cancer cells divide.<\/p>\n<p>A collaborative team led by Agnieszka Witkiewicz, MD, Professor of Oncology, and Erik Knudsen, Ph.D., Professor of Oncology and Chair of Molecular and Cellular Biology, from Roswell Park investigated over 500 <a href=\"https:\/\/medicalxpress.com\/tags\/cell+lines\/\" rel=\"tag\" class=\"\">cell lines<\/a> from a multitude of cancer types, as well as preclinical tumor models. The researchers then analyzed <a href=\"https:\/\/medicalxpress.com\/tags\/cancer+cells\/\" rel=\"tag\" class=\"\">cancer cells<\/a> based on their dependency for CDK and CCN, two genes that drive the cell cycle and determine how often a cancer cell divides.<\/p>\n<p>\u201cWe found that the way cancer cells divide is highly varied, and that diversity represents a tremendous challenge for some widely used cancer therapies because it often contributes to treatment resistance,\u201d says Dr. Witkiewicz, the study\u2019s senior author. \u201cHowever, with a better understanding of these heterogenous features of cancer cell division, different therapies could be deployed in a more precise and effective fashion.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists from Roswell Park Comprehensive Cancer Center have shed light on a different way of overcoming mechanisms of resistance to specific therapeutic agents used to treat cancer. In a new article published March 1 in the journal Cell Reports, the researchers propose a new approach to cancer treatment based on the way different cancer cells [\u2026]<\/p>\n","protected":false},"author":461,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-136407","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/136407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/461"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=136407"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/136407\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=136407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=136407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=136407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}