{"id":135421,"date":"2022-02-09T21:24:49","date_gmt":"2022-02-10T05:24:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/02\/mini-brains-grown-in-a-lab-provide-clues-about-early-life-origins-of-schizophrenia"},"modified":"2022-02-09T21:24:49","modified_gmt":"2022-02-10T05:24:49","slug":"mini-brains-grown-in-a-lab-provide-clues-about-early-life-origins-of-schizophrenia","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/02\/mini-brains-grown-in-a-lab-provide-clues-about-early-life-origins-of-schizophrenia","title":{"rendered":"\u201cMini-Brains\u201d Grown in a Lab Provide Clues About Early Life Origins of Schizophrenia"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mini-brains-grown-in-a-lab-provide-clues-about-early-life-origins-of-schizophrenia.jpg\"><\/a><\/p>\n<p>Multiple changes in brain cells during the first month of embryonic development may contribute to schizophrenia later in life, according to a new study by Weill Cornell Medicine investigators.<\/p>\n<p>The researchers, whose study was published in <i>Molecular Psychiatry<\/i>, used stem cells collected from patients with schizophrenia and people without the disease to grow 3-dimensional \u201cmini-brains\u201d or organoids in the laboratory. By comparing the development of both sets of organoids, they discovered that a reduced expression of two genes in the cells stymies early development and causes a shortage of brain cells in organoids grown from patient stem cells.<\/p>\n<p>\u201cThis discovery fills an important gap in scientists\u2019 understanding of schizophrenia,\u201d said senior author Dr. Dilek Colak, assistant professor of neuroscience at the Feil Family Brain and Mind Institute and the Center for Neurogenetics at Weill Cornell Medicine. Symptoms of schizophrenia typically develop in adulthood, but postmortem studies of the brains of people with the disease found enlarged cavities called ventricles and differences in the cortical layers that likely occurred early in life.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Multiple changes in brain cells during the first month of embryonic development may contribute to schizophrenia later in life, according to a new study by Weill Cornell Medicine investigators. The researchers, whose study was published in Molecular Psychiatry, used stem cells collected from patients with schizophrenia and people without the disease to grow 3-dimensional \u201cmini-brains\u201d [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-135421","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/135421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=135421"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/135421\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=135421"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=135421"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=135421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}