{"id":134648,"date":"2022-01-25T07:23:33","date_gmt":"2022-01-25T15:23:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/01\/team-demonstrates-molecular-electronics-sensors-on-a-semiconductor-chip"},"modified":"2022-01-25T07:23:33","modified_gmt":"2022-01-25T15:23:33","slug":"team-demonstrates-molecular-electronics-sensors-on-a-semiconductor-chip","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/01\/team-demonstrates-molecular-electronics-sensors-on-a-semiconductor-chip","title":{"rendered":"Team demonstrates molecular electronics sensors on a semiconductor chip"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/team-demonstrates-molecular-electronics-sensors-on-a-semiconductor-chip2.jpg\"><\/a><\/p>\n<p>The first molecular electronics chip has been developed, realizing a 50-year-old goal of integrating single molecules into circuits to achieve the ultimate scaling limits of Moore\u2019s Law. Developed by Roswell Biotechnologies and a multi-disciplinary team of leading academic scientists, the chip uses single molecules as universal sensor elements in a circuit to create a programmable biosensor with real-time, single-molecule sensitivity and unlimited scalability in sensor pixel density. This innovation, appearing this week in a peer-reviewed article in the <i><i>Proceedings of the National Academy of Sciences<\/i> (PNAS)<\/i>, will power advances in diverse fields that are fundamentally based on observing molecular interactions, including drug discovery, diagnostics, DNA sequencing, and proteomics.<\/p>\n<p>\u201cBiology works by <a href=\"https:\/\/phys.org\/tags\/single+molecules\/\" rel=\"tag\" class=\"\">single molecules<\/a> talking to each other, but our existing measurement methods cannot detect this,\u201d said co-author Jim Tour, Ph.D., a Rice University chemistry professor and a pioneer in the field of molecular electronics. \u201cThe <a href=\"https:\/\/phys.org\/tags\/sensors\/\" rel=\"tag\" class=\"\">sensors<\/a> demonstrated in this paper for the first time let us listen in on these molecular communications, enabling a new and powerful view of biological information.\u201d<\/p>\n<p>The molecular electronics platform consists of a programmable semiconductor chip with a scalable sensor array architecture. Each array element consists of an electrical current meter that monitors the current flowing through a precision-engineered molecular wire, assembled to span nanoelectrodes that couple it directly into the circuit. The sensor is programmed by attaching the desired probe molecule to the molecular wire, via a central, engineered conjugation site. The observed current provides a direct, <a href=\"https:\/\/phys.org\/tags\/real-time\/\" rel=\"tag\" class=\"\">real-time<\/a> electronic readout of molecular interactions of the probe. These picoamp-scale current-versus-time measurements are read out from the sensor array in digital form, at a rate of 1,000 frames per second, to capture molecular interactions data with high resolution, precision and throughput.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The first molecular electronics chip has been developed, realizing a 50-year-old goal of integrating single molecules into circuits to achieve the ultimate scaling limits of Moore\u2019s Law. Developed by Roswell Biotechnologies and a multi-disciplinary team of leading academic scientists, the chip uses single molecules as universal sensor elements in a circuit to create a programmable [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523],"tags":[],"class_list":["post-134648","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/134648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=134648"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/134648\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=134648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=134648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=134648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}