{"id":130723,"date":"2021-11-17T01:22:17","date_gmt":"2021-11-17T09:22:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/11\/clinical-trial-of-nasal-vaccine-for-alzheimers-disease-underway-at-boston-hospital"},"modified":"2021-11-17T01:22:17","modified_gmt":"2021-11-17T09:22:17","slug":"clinical-trial-of-nasal-vaccine-for-alzheimers-disease-underway-at-boston-hospital","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/11\/clinical-trial-of-nasal-vaccine-for-alzheimers-disease-underway-at-boston-hospital","title":{"rendered":"Clinical trial of nasal vaccine for Alzheimer\u2019s disease underway at Boston hospital"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/clinical-trial-of-nasal-vaccine-for-alzheimers-disease-underway-at-boston-hospital2.jpg\"><\/a><\/p>\n<p>It is designed to activate white blood cells found in the lymph nodes on the sides and back of the neck to migrate to the brain and trigger clearance of beta-amyloid plaques \u2014 one of the hallmarks of Alzheimer\u2019s. I-Mab Biopharma (I-Mab) and Jiangsu Nhwa Pharmaceutical (NHWA) are responsible for the development, manufacturing and commercialization of Protollin.<\/p>\n<p>The trial represents the culmination of nearly 20 years of research led by Dr. Howard L. Weiner, co-director of the Ann Romney Center for Neurologic Diseases at the Brigham.<\/p>\n<p>\u201cThe launch of the first human trial of a nasal vaccine for Alzheimer\u2019s is a remarkable milestone,\u201d said Weiner. \u201cOver the last two decades, we\u2019ve amassed preclinical evidence suggesting the potential of this nasal vaccine for AD. If clinical trials in humans show that the vaccine is safe and effective, this could represent a nontoxic treatment for people with Alzheimer\u2019s, and it could also be given early to help prevent Alzheimer\u2019s in people at risk.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is designed to activate white blood cells found in the lymph nodes on the sides and back of the neck to migrate to the brain and trigger clearance of beta-amyloid plaques \u2014 one of the hallmarks of Alzheimer\u2019s. I-Mab Biopharma (I-Mab) and Jiangsu Nhwa Pharmaceutical (NHWA) are responsible for the development, manufacturing and commercialization [\u2026]<\/p>\n","protected":false},"author":359,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-130723","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/130723","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/359"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=130723"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/130723\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=130723"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=130723"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=130723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}