{"id":130601,"date":"2021-11-14T12:43:55","date_gmt":"2021-11-14T20:43:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/11\/xist-marks-the-spot-how-an-rna-molecule-silences-the-x-chromosome"},"modified":"2021-11-14T12:43:55","modified_gmt":"2021-11-14T20:43:55","slug":"xist-marks-the-spot-how-an-rna-molecule-silences-the-x-chromosome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/11\/xist-marks-the-spot-how-an-rna-molecule-silences-the-x-chromosome","title":{"rendered":"Xist marks the spot: How an RNA molecule silences the X chromosome"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/xist-marks-the-spot-how-an-rna-molecule-silences-the-x-chromosome2.jpg\"><\/a><\/p>\n<p>In one of the mysteries of mammalian development, every cell in the early female embryo shuts down one of its two copies of the X chromosome, leaving just one functional. For years, the mechanics behind this X chromosome inactivation have been murky, but scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have now taken a major step forward in understanding the process.<\/p>\n<p>Their findings, based on research on mouse stem cells, upend previous assumptions about how X inactivation is initiated in female embryos and could lead to new ways to treat some genetic disorders, as well as a better understanding of how genes on other chromosomes are silenced.<\/p>\n<p>\u201cX inactivation is one of the most fundamentally important processes in development, and I think this study is a slam dunk in finally understanding it,\u201d said Kathrin Plath, a professor of biological chemistry and senior author of the paper, published in the journal <i>Cell<\/i>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In one of the mysteries of mammalian development, every cell in the early female embryo shuts down one of its two copies of the X chromosome, leaving just one functional. For years, the mechanics behind this X chromosome inactivation have been murky, but scientists from the Eli and Edythe Broad Center of Regenerative Medicine and [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-130601","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/130601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=130601"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/130601\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=130601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=130601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=130601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}