{"id":130518,"date":"2021-11-13T04:23:20","date_gmt":"2021-11-13T12:23:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/11\/metformin-impairs-exercise-training-related-improvements-in-older-adults"},"modified":"2021-11-13T04:23:20","modified_gmt":"2021-11-13T12:23:20","slug":"metformin-impairs-exercise-training-related-improvements-in-older-adults","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/11\/metformin-impairs-exercise-training-related-improvements-in-older-adults","title":{"rendered":"Metformin Impairs Exercise Training-Related Improvements In Older Adults"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/hppeWELvZtQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Join us on Patreon!<br \/>\n<a href=\"https:\/\/www.patreon.com\/MichaelLustgartenPhD\">https:\/\/www.patreon.com\/MichaelLustgartenPhD<\/a><\/p>\n<p>Papers referenced in the video:<br \/> Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34725961\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34725961\/<\/a><\/p>\n<p>Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31557380\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31557380\/<\/a><\/p>\n<p>Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30548390\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30548390\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Join us on Patreon! https:\/\/www.patreon.com\/MichaelLustgartenPhD Papers referenced in the video: Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a. https:\/\/pubmed.ncbi.nlm.nih.gov\/34725961\/ Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial. https:\/\/pubmed.ncbi.nlm.nih.gov\/31557380\/ Metformin inhibits mitochondrial adaptations to aerobic exercise [\u2026]<\/p>\n","protected":false},"author":587,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-130518","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/130518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/587"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=130518"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/130518\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=130518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=130518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=130518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}