{"id":129648,"date":"2021-10-28T16:22:25","date_gmt":"2021-10-28T23:22:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/10\/the-spike-protein-of-sars-cov-2-variant-a-30-is-heavily-mutated-and-evades-vaccine-induced-antibodies-with-high-efficiency"},"modified":"2021-10-28T16:22:25","modified_gmt":"2021-10-28T23:22:25","slug":"the-spike-protein-of-sars-cov-2-variant-a-30-is-heavily-mutated-and-evades-vaccine-induced-antibodies-with-high-efficiency","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/10\/the-spike-protein-of-sars-cov-2-variant-a-30-is-heavily-mutated-and-evades-vaccine-induced-antibodies-with-high-efficiency","title":{"rendered":"The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-spike-protein-of-sars-cov-2-variant-a-30-is-heavily-mutated-and-evades-vaccine-induced-antibodies-with-high-efficiency.jpg\"><\/a><\/p>\n<p>The COVID-19 pandemic, caused by SARS-CoV-2, continues to rage in many countries, straining health systems and economies. Vaccines protect against severe disease and death and are considered central to ending the pandemic. COVID-19 vaccines (and SARS-CoV-2 infection) elicit antibodies that are directed against the viral spike (S) protein and neutralize the virus. However, the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1]. Furthermore, emerging viral variants with enhanced transmissibility, likely due to altered virus-host cell interactions, might rapidly spread globally. Therefore, it is important to investigate whether emerging SARS-CoV-2 variants exhibit altered host cell interactions and resistance against antibody-mediated neutralization.<\/p>\n<hr>\n<p>\n<a data-test=\"journal-link\" href=\"https:\/\/www.nature.com\/cmi\"><i>Cellular &amp; Molecular Immunology<\/i><\/a> (2021) <a href=\"https:\/\/www.nature.com\/articles\/s41423-021-00779-5#citeas\" class=\"\">Cite this article<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The COVID-19 pandemic, caused by SARS-CoV-2, continues to rage in many countries, straining health systems and economies. Vaccines protect against severe disease and death and are considered central to ending the pandemic. COVID-19 vaccines (and SARS-CoV-2 infection) elicit antibodies that are directed against the viral spike (S) protein and neutralize the virus. However, the emergence [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,39,1495],"tags":[],"class_list":["post-129648","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-economics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/129648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=129648"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/129648\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=129648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=129648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=129648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}