{"id":128980,"date":"2021-10-14T10:23:57","date_gmt":"2021-10-14T17:23:57","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/10\/brains-white-matter-integrity-disrupted-in-people-with-alzheimers-gene-mutation"},"modified":"2021-10-14T10:23:57","modified_gmt":"2021-10-14T17:23:57","slug":"brains-white-matter-integrity-disrupted-in-people-with-alzheimers-gene-mutation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/10\/brains-white-matter-integrity-disrupted-in-people-with-alzheimers-gene-mutation","title":{"rendered":"Brain\u2019s White Matter Integrity Disrupted in People With Alzheimer\u2019s Gene Mutation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brains-white-matter-integrity-disrupted-in-people-with-alzheimers-gene-mutation2.jpg\"><\/a><\/p>\n<p>The structural integrity of the brain\u2019s white matter as measured with an advanced MRI technique is lower in cognitively normal people who carry a genetic mutation associated with Alzheimer\u2019s disease than it is in non-carriers, according to a study in <em>Radiology<\/em>. Researchers said the findings show the promise of widely available imaging techniques in helping to understand early structural changes in the brain before symptoms of dementia become apparent.<\/p>\n<p>People who carry the autosomal dominant Alzheimer disease (ADAD) mutation have a higher risk of Alzheimer\u2019s disease, a type of dementia that affects about one in nine people in the United States. The mutation is linked to a buildup of abnormal protein called amyloid-beta in the brain that affects both the gray matter and the signal-carrying white matter.<\/p>\n<p>\u201cIt\u2019s thought that the amyloid deposition in the gray matter could disrupt its function, and as a result the white matter won\u2019t function correctly or could even atrophy,\u201d said study lead author Jeffrey W. Prescott, M.D., Ph.D., neuroradiologist at the MetroHealth Medical Center in Cleveland.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The structural integrity of the brain\u2019s white matter as measured with an advanced MRI technique is lower in cognitively normal people who carry a genetic mutation associated with Alzheimer\u2019s disease than it is in non-carriers, according to a study in Radiology. Researchers said the findings show the promise of widely available imaging techniques in helping [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-128980","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/128980","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=128980"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/128980\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=128980"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=128980"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=128980"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}