{"id":128762,"date":"2021-10-09T04:22:28","date_gmt":"2021-10-09T11:22:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/10\/researchers-demonstrate-vaccination-approach-in-mice-that-could-prevent-future-coronavirus-outbreaks"},"modified":"2021-10-09T04:22:28","modified_gmt":"2021-10-09T11:22:28","slug":"researchers-demonstrate-vaccination-approach-in-mice-that-could-prevent-future-coronavirus-outbreaks","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/10\/researchers-demonstrate-vaccination-approach-in-mice-that-could-prevent-future-coronavirus-outbreaks","title":{"rendered":"Researchers demonstrate vaccination approach in mice that could prevent future coronavirus outbreaks"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-demonstrate-vaccination-approach-in-mice-that-could-prevent-future-coronavirus-outbreaks3.jpg\"><\/a><\/p>\n<p>Researchers in Japan have developed a vaccination strategy in mice that promotes the production of antibodies that can neutralize not only SARS-CoV-2 but a broad range of other coronaviruses as well. If successfully translated to humans, the approach, to be published October 8 in the <i>Journal of Experimental Medicine<\/i>, could lead to the development of a next-generation vaccine capable of preventing future coronavirus pandemics.<\/p>\n<p>The SARS-CoV-2 virus responsible for COVID-19 enters human cells by using its <a href=\"https:\/\/medicalxpress.com\/tags\/spike+protein\/\" rel=\"tag\" class=\"\">spike protein<\/a> to bind to a <a href=\"https:\/\/medicalxpress.com\/tags\/cell+surface+receptor\/\" rel=\"tag\" class=\"\">cell surface receptor<\/a> called ACE2. The receptor-binding domain of the spike protein consists of two parts: a \u201ccore\u201d region that is very similar in all coronaviruses, and a more specialized \u201chead\u201d region that mediates binding to ACE2.<\/p>\n<p>Antibodies that recognize the head region of the spike receptor-binding domain can block the entry of SARS-CoV-2 into cells but offer little protection against other coronaviruses, such as the SARS-CoV-1 virus responsible for the severe acute respiratory syndrome outbreak of 2002. Antibodies that recognize the core region of the spike receptor-binding domain, in contrast, can prevent the entry of various coronaviruses into <a href=\"https:\/\/medicalxpress.com\/tags\/human+cells\/\" rel=\"tag\" class=\"\">human cells<\/a>. Unfortunately, however, individuals exposed to the viral spike protein tend to produce lots of <a href=\"https:\/\/medicalxpress.com\/tags\/antibodies\/\" rel=\"tag\" class=\"\">antibodies<\/a> against the head region but few, if any, antibodies that recognize the core region.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers in Japan have developed a vaccination strategy in mice that promotes the production of antibodies that can neutralize not only SARS-CoV-2 but a broad range of other coronaviruses as well. If successfully translated to humans, the approach, to be published October 8 in the Journal of Experimental Medicine, could lead to the development of [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,20],"tags":[],"class_list":["post-128762","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/128762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=128762"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/128762\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=128762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=128762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=128762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}