{"id":128076,"date":"2021-09-25T00:22:31","date_gmt":"2021-09-25T07:22:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/09\/researchers-turn-back-the-clock-on-heart-cells-in-mice"},"modified":"2021-09-25T00:22:31","modified_gmt":"2021-09-25T07:22:31","slug":"researchers-turn-back-the-clock-on-heart-cells-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/09\/researchers-turn-back-the-clock-on-heart-cells-in-mice","title":{"rendered":"Researchers Turn Back the Clock on Heart Cells in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-turn-back-the-clock-on-heart-cells-in-mice2.jpg\"><\/a><\/p>\n<p>Researchers turn back the clock on heart cells via yamanaka factors in mice.<\/p>\n<hr>\n<p>Scientists may have found a way for the heart to gain regenerative capabilities, offering a potential silver lining for patients who have suffered a heart attack.<\/p>\n<p>Researchers from the <strong><a href=\"https:\/\/www.biospace.com\/employer\/525443\/max-planck-institute\/\" target=\"_blank\">Max Planck Institute for Heart and Lung Research<\/a> <\/strong>reportedly achieved positive results after returning adult cardiomyocytes to their fetal-like state in mouse models. To make this happen, they selectively expressed four genes, collectively called<strong> <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abg5159\" target=\"_blank\">OSKM<\/a><\/strong>, which are necessary for cell renewal \u2014 Oct4, Sox2, Klf4, and c-Myc.<\/p>\n<p>Cardiomyocyte replacement can be extremely slow in adult mammalian hearts, which prevents the healing of damaged myocardium post-injury, but fetal hearts are able to regenerate because their less mature CMs still have the ability to proliferate.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers turn back the clock on heart cells via yamanaka factors in mice. Scientists may have found a way for the heart to gain regenerative capabilities, offering a potential silver lining for patients who have suffered a heart attack. Researchers from the Max Planck Institute for Heart and Lung Research reportedly achieved positive results after [\u2026]<\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-128076","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/128076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=128076"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/128076\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=128076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=128076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=128076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}