{"id":127761,"date":"2021-09-17T06:22:21","date_gmt":"2021-09-17T13:22:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/09\/molnupiravir-coding-for-catastrophe"},"modified":"2021-09-17T06:22:21","modified_gmt":"2021-09-17T13:22:21","slug":"molnupiravir-coding-for-catastrophe","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/09\/molnupiravir-coding-for-catastrophe","title":{"rendered":"Molnupiravir: coding for catastrophe"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/molnupiravir-coding-for-catastrophe.jpg\"><\/a><\/p>\n<p>Molnupiravir, a wide-spectrum antiviral that is currently in phase 2\/3 clinical trials for the treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as \u2018lethal mutagenesis\u2019. Two recently published studies reveal the biochemical and structural bases of how molnupiravir disrupts the fidelity of SARS-CoV-2 genome replication and prevents viral propagation by fostering error accumulation in a process referred to as \u2018error catastrophe\u2019.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molnupiravir, a wide-spectrum antiviral that is currently in phase 2\/3 clinical trials for the treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as \u2018lethal mutagenesis\u2019. Two recently published studies reveal the biochemical and structural bases of how molnupiravir disrupts the fidelity of SARS-CoV-2 genome replication and prevents viral propagation by [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-127761","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/127761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=127761"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/127761\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=127761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=127761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=127761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}