{"id":127446,"date":"2021-09-09T12:22:18","date_gmt":"2021-09-09T19:22:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/09\/gene-self-correction-in-chromosome-caps-can-beat-mutations-help-prevent-blood-cancers"},"modified":"2021-09-09T12:22:18","modified_gmt":"2021-09-09T19:22:18","slug":"gene-self-correction-in-chromosome-caps-can-beat-mutations-help-prevent-blood-cancers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/09\/gene-self-correction-in-chromosome-caps-can-beat-mutations-help-prevent-blood-cancers","title":{"rendered":"Gene self-correction in \u2018chromosome caps\u2019 can beat mutations, help prevent blood cancers"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gene-self-correction-in-chromosome-caps-can-beat-mutations-help-prevent-blood-cancers.jpg\"><\/a><\/p>\n<p>Mentions telomeres.<\/p>\n<p>~~~<\/p>\n<hr>\n<p>People with rare disorders that cause shortened telomeres\u2014protective caps that sit at the end of chromosomes\u2014may be more likely to have blood cancers such as leukemia or myelodyplastic syndrome. Now, Johns Hopkins Medicine scientists have discovered several \u201cself-correcting\u201d genetic mutations in bone marrow that may protect such patients from these cancers.<\/p>\n<p>In a study published online August 3 2021, in the <i>Journal of Clinical Investigation<\/i>, the researchers also suggest these mutations can serve as biomarkers that may indicate if patients with short telomere syndromes are likely to develop blood cancers.<\/p>\n<p>\u201cThese are the most common cancers we see in patients with short telomere syndromes,\u201d says Mary Armanios, M.D., director of the Telomere Center and professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. \u201cWe know that at a certain point, the cells of patients with shortened <a href=\"https:\/\/medicalxpress.com\/tags\/telomeres\/\" rel=\"tag\" class=\"\">telomeres<\/a> either become cancerous or stay healthy.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mentions telomeres. ~~~ People with rare disorders that cause shortened telomeres\u2014protective caps that sit at the end of chromosomes\u2014may be more likely to have blood cancers such as leukemia or myelodyplastic syndrome. Now, Johns Hopkins Medicine scientists have discovered several \u201cself-correcting\u201d genetic mutations in bone marrow that may protect such patients from these cancers. In [\u2026]<\/p>\n","protected":false},"author":426,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-127446","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/127446","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/426"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=127446"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/127446\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=127446"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=127446"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=127446"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}