{"id":126724,"date":"2021-08-25T11:22:18","date_gmt":"2021-08-25T18:22:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/08\/genes-for-alcohol-use-disorder-and-alzheimers-risk-overlap-study"},"modified":"2021-08-25T11:22:18","modified_gmt":"2021-08-25T18:22:18","slug":"genes-for-alcohol-use-disorder-and-alzheimers-risk-overlap-study","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/08\/genes-for-alcohol-use-disorder-and-alzheimers-risk-overlap-study","title":{"rendered":"Genes for Alcohol Use Disorder and Alzheimer\u2019s Risk Overlap: Study"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/genes-for-alcohol-use-disorder-and-alzheimers-risk-overlap-study.jpg\"><\/a><\/p>\n<p>ABOVE: MAPT, one of the genes linked to both heavy drinking and neurodegenerative diseases, codes for the protein tau (blue in this illustration) inside a neuron. NATIONAL INSTITUTE ON AGING\/ NATIONAL INSTITUTES OF HEALTH<\/p>\n<p>Some genetic risk factors for alcohol use disorder overlap with those for neurodegenerative diseases like Alzheimer\u2019s, scientists reported in <a href=\"https:\/\/www.nature.com\/articles\/s41467-021-25392-y\" target=\"_blank\"><em>Nature Communications<\/em><\/a> on August 20. The study, which relied on a combination of genetic, transcriptomic, and epigenetic data, also offers insight into the molecular commonalities among these disorders, and their connections to immune disfunction.<\/p>\n<p>\u201cBy meshing findings from genome wide association studies\u2026 ith gene expression in brain and other tissues, this new study has prioritized genes likely to harbor regulatory variants influencing risk of Alcohol Use Disorder,\u201d writes David Goldman, a neurogenetics researcher at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in an email to <em>The Scientist<\/em>. \u201cSeveral of these genes are also associated with neurodegenerative disorders\u2014an intriguing connection because of alcohol\u2019s ability to prematurely age the brain.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ABOVE: MAPT, one of the genes linked to both heavy drinking and neurodegenerative diseases, codes for the protein tau (blue in this illustration) inside a neuron. NATIONAL INSTITUTE ON AGING\/ NATIONAL INSTITUTES OF HEALTH Some genetic risk factors for alcohol use disorder overlap with those for neurodegenerative diseases like Alzheimer\u2019s, scientists reported in Nature Communications [\u2026]<\/p>\n","protected":false},"author":621,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-126724","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/126724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/621"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=126724"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/126724\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=126724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=126724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=126724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}