{"id":126605,"date":"2021-08-22T08:23:22","date_gmt":"2021-08-22T15:23:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/08\/northwestern-scientists-discover-remarkable-longevity-in-a-subset-of-mitochondrial-proteins"},"modified":"2021-08-22T08:23:22","modified_gmt":"2021-08-22T15:23:22","slug":"northwestern-scientists-discover-remarkable-longevity-in-a-subset-of-mitochondrial-proteins","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/08\/northwestern-scientists-discover-remarkable-longevity-in-a-subset-of-mitochondrial-proteins","title":{"rendered":"Northwestern scientists discover remarkable longevity in a subset of mitochondrial proteins"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/northwestern-scientists-discover-remarkable-longevity-in-a-subset-of-mitochondrial-proteins.jpg\"><\/a><\/p>\n<p>Northwestern Medicine investigators have discovered that a subset of proteins in mitochondria of brain and heart cells are long-lived, supporting the long-term stability of mitochondrial complex architecture.<\/p>\n<p>The study, published in the <em>Journal of Cell Biology<\/em>, was led by Jeffrey Savas, PhD, assistant professor in the Ken &amp; Ruth Davee Department of Neurology\u2019s Division of Behavioral Neurology, of Medicine the in Division of Nephrology and Hypertension, and of Pharmacology.<\/p>\n<p>Previous work led by Savas discovered that nuclear pore complex proteins in post-mitotic neurons are exceptionally long-lived and persist for months in mouse and rat brains. These proteins, termed long-lived proteins, or LLPs, provide long-term stability and structure to the nuclear pore and subsequently to the nuclear envelope of neurons; however, this concept had never been considered for other intracellular organelles, until now.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Northwestern Medicine investigators have discovered that a subset of proteins in mitochondria of brain and heart cells are long-lived, supporting the long-term stability of mitochondrial complex architecture. The study, published in the Journal of Cell Biology, was led by Jeffrey Savas, PhD, assistant professor in the Ken &amp; Ruth Davee Department of Neurology\u2019s Division of [\u2026]<\/p>\n","protected":false},"author":359,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-126605","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/126605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/359"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=126605"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/126605\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=126605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=126605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=126605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}