{"id":126391,"date":"2021-08-17T15:22:28","date_gmt":"2021-08-17T22:22:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/08\/gene-therapy-uses-sirt6-variant-found-in-centenarians"},"modified":"2021-08-17T15:22:28","modified_gmt":"2021-08-17T22:22:28","slug":"gene-therapy-uses-sirt6-variant-found-in-centenarians","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/08\/gene-therapy-uses-sirt6-variant-found-in-centenarians","title":{"rendered":"Gene therapy uses SIRT6 variant found in centenarians"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gene-therapy-uses-sirt6-variant-found-in-centenarians.jpg\"><\/a><\/p>\n<p>\u201cSo many genes are involved in DNA maintenance, FOXO3 for example, which is very interesting, but it cannot be a therapeutic target because it will trigger a lot of other things,\u201d he explains. \u201cSIRT6 is coding for only one protein and, because it\u2019s a small protein, the cargo size is not too big and it can be easily delivered into cells, so it\u2019s possible to use it as a gene therapy target.\u201d<\/p>\n<p>Some of the other factors that play in Genflow\u2019s favour, says Leire, are that the world has reached a better understanding of the biology of aging, but also that gene therapy has also progressed well over the years.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cSo many genes are involved in DNA maintenance, FOXO3 for example, which is very interesting, but it cannot be a therapeutic target because it will trigger a lot of other things,\u201d he explains. \u201cSIRT6 is coding for only one protein and, because it\u2019s a small protein, the cargo size is not too big and it [\u2026]<\/p>\n","protected":false},"author":388,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-126391","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/126391","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/388"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=126391"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/126391\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=126391"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=126391"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=126391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}