{"id":126256,"date":"2021-08-15T21:22:26","date_gmt":"2021-08-16T04:22:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/08\/brain-cholesterol-regulates-alzheimers-plaques"},"modified":"2021-08-15T21:22:26","modified_gmt":"2021-08-16T04:22:26","slug":"brain-cholesterol-regulates-alzheimers-plaques","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/08\/brain-cholesterol-regulates-alzheimers-plaques","title":{"rendered":"Brain Cholesterol Regulates Alzheimer\u2019s Plaques"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brain-cholesterol-regulates-alzheimers-plaques.jpg\"><\/a><\/p>\n<p>\u201cWe showed that cholesterol is acting essentially as a signal in neurons that determines how much A\u03b2 gets made\u2014and thus it should be unsurprising that apoE, which carries the cholesterol to neurons, influences Alzheimer\u2019s risk,\u201d says study co-senior author Scott Hansen, PhD, an associate professor in the Department of Molecular Medicine at Scripps Research, Florida.<\/p>\n<hr>\n<p>\n<strong><em>Summary: <\/em><\/strong><em>A new advanced imaging technique shows how cholesterol regulates the production of Alzheimer\u2019s associated amyloid beta proteins in astrocytes.<\/em><\/p>\n<p><strong><em>Source: <\/em><\/strong><em>Scripps Research Institute<\/em><\/p>\n<p><strong>A team co-led by scientists at Scripps Research has used advanced imaging methods to reveal how the production of the Alzheimer\u2019s-associated protein amyloid beta (A\u03b2) in the brain is tightly regulated by cholesterol.<\/strong><\/p>\n<p>Appearing on line Thursday ahead of print in the Aug. 17 issue of the <em>Proceedings of the National Academy of Sciences (PNAS)<\/em>, the scientists\u2019 work advances understanding of how Alzheimer\u2019s disease develops and underscores the long-underappreciated role of brain cholesterol.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cWe showed that cholesterol is acting essentially as a signal in neurons that determines how much A\u03b2 gets made\u2014and thus it should be unsurprising that apoE, which carries the cholesterol to neurons, influences Alzheimer\u2019s risk,\u201d says study co-senior author Scott Hansen, PhD, an associate professor in the Department of Molecular Medicine at Scripps Research, Florida. [\u2026]<\/p>\n","protected":false},"author":621,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-126256","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/126256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/621"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=126256"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/126256\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=126256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=126256"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=126256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}