{"id":125878,"date":"2021-08-05T15:22:30","date_gmt":"2021-08-05T22:22:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/08\/marijuana-like-brain-substance-calms-seizures-but-increases-after-effects"},"modified":"2021-08-05T15:22:30","modified_gmt":"2021-08-05T22:22:30","slug":"marijuana-like-brain-substance-calms-seizures-but-increases-after-effects","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/08\/marijuana-like-brain-substance-calms-seizures-but-increases-after-effects","title":{"rendered":"Marijuana-Like Brain Substance Calms Seizures but Increases After-Effects"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/marijuana-like-brain-substance-calms-seizures-but-increases-after-effects2.jpg\"><\/a><\/p>\n<p>But 2-AG is almost immediately converted to arachidonic acid, a building block for inflammatory compounds called prostaglandins. The researchers showed that the ensuing increase in arachidonic acid levels resulted in the buildup of a particular variety of prostaglandin that causes constriction of tiny blood vessels in the brain where the seizure has induced thatprostaglandin\u2019s production, cutting off oxygen supply to those brain areas.<\/p>\n<hr>\n<p>\n<strong><em>Summary: <\/em><\/strong><em>The release of 2-AG, a natural endocannabinoid that is suggested to be the brain\u2019s equivalent to THC, dampens down seizure activity but increases post-seizure oxygen deprivation in the brain.<\/em><\/p>\n<p><strong><em>Source: <\/em><\/strong><em>Stanford<\/em><\/p>\n<p><strong>A marijuana-like chemical in the brain, mirroring its plant-based counterpart, packs both ups and downs.<\/strong><\/p>\n<p>Epileptic seizures trigger the rapid synthesis and release of a substance mimicked by marijuana\u2019s most psychoactive component, Stanford University School of Medicine investigators have learned. This substance is called 2-arachidonoylglycerol, or 2-AG, and has the beneficial effect of damping down seizure intensity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>But 2-AG is almost immediately converted to arachidonic acid, a building block for inflammatory compounds called prostaglandins. The researchers showed that the ensuing increase in arachidonic acid levels resulted in the buildup of a particular variety of prostaglandin that causes constriction of tiny blood vessels in the brain where the seizure has induced thatprostaglandin\u2019s production, [\u2026]<\/p>\n","protected":false},"author":621,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,47],"tags":[],"class_list":["post-125878","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/125878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/621"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=125878"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/125878\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=125878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=125878"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=125878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}