{"id":125777,"date":"2021-08-03T11:24:37","date_gmt":"2021-08-03T18:24:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/08\/cryptic-transcription-in-mammalian-stem-cells-linked-to-aging"},"modified":"2021-08-03T11:24:37","modified_gmt":"2021-08-03T18:24:37","slug":"cryptic-transcription-in-mammalian-stem-cells-linked-to-aging","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/08\/cryptic-transcription-in-mammalian-stem-cells-linked-to-aging","title":{"rendered":"Cryptic transcription in mammalian stem cells linked to aging"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cryptic-transcription-in-mammalian-stem-cells-linked-to-aging2.jpg\"><\/a><\/p>\n<p>Although visible signs of aging are usually unmistakable, unraveling what triggers them has been quite a challenge. Researchers at Baylor College of Medicine and collaborating institutions have discovered that a cellular phenomenon called cryptic transcription, which had been previously described and linked to aging in yeasts and worms, is elevated in aging mammalian stem cells.<\/p>\n<p>The team reports in the journal <i>Nature Aging<\/i> that cryptic transcription occurs because a <a href=\"https:\/\/medicalxpress.com\/tags\/cellular+mechanism\/\" rel=\"tag\" class=\"\">cellular mechanism<\/a> that keeps it in check falls apart as cells get old. The findings suggest that strategies that control cryptic transcription could have pro-longevity effects.<\/p>\n<p>\u201cIn previous work, we showed that cryptic transcription in yeasts and worms is not only a marker of aging but also a cause,\u201d said corresponding author Dr. Weiwei Dang, assistant professor of molecular and <a href=\"https:\/\/medicalxpress.com\/tags\/human+genetics\/\" rel=\"tag\" class=\"\">human genetics<\/a> and the Huffington Center on Aging at Baylor. \u201cReducing the amount of this aberrant transcription in these organisms prolonged their lifespan.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Although visible signs of aging are usually unmistakable, unraveling what triggers them has been quite a challenge. Researchers at Baylor College of Medicine and collaborating institutions have discovered that a cellular phenomenon called cryptic transcription, which had been previously described and linked to aging in yeasts and worms, is elevated in aging mammalian stem cells. [\u2026]<\/p>\n","protected":false},"author":426,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-125777","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/125777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/426"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=125777"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/125777\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=125777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=125777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=125777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}