{"id":124574,"date":"2021-07-03T22:22:43","date_gmt":"2021-07-04T05:22:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/07\/scientists-publish-a-how-to-guide-for-creating-mouse-human-chimeric-embryos"},"modified":"2021-07-03T22:22:43","modified_gmt":"2021-07-04T05:22:43","slug":"scientists-publish-a-how-to-guide-for-creating-mouse-human-chimeric-embryos","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/07\/scientists-publish-a-how-to-guide-for-creating-mouse-human-chimeric-embryos","title":{"rendered":"Scientists publish a how-to guide for creating mouse-human chimeric embryos"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-publish-a-how-to-guide-for-creating-mouse-human-chimeric-embryos2.jpg\"><\/a><\/p>\n<p>A year after University at Buffalo scientists demonstrated that it was possible to produce millions of mature human cells in a mouse embryo, they have published a detailed description of the method so that other laboratories can do it, too.<\/p>\n<p>The ability to produce millions of mature human <a href=\"https:\/\/phys.org\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a> in a living organism, called a chimera, which contains the cells of two species, is critical if the ultimate promise of <a href=\"https:\/\/phys.org\/tags\/stem+cells\/\" rel=\"tag\" class=\"\">stem cells<\/a> to treat or cure <a href=\"https:\/\/phys.org\/tags\/human+disease\/\" rel=\"tag\" class=\"\">human disease<\/a> is to be realized. But to produce those mature cells, human primed stem cells must be converted back into an earlier, less developed naive state so that the <a href=\"https:\/\/phys.org\/tags\/human+stem+cells\/\" rel=\"tag\" class=\"\">human stem cells<\/a> can co-develop with the inner cell mass in a <a href=\"https:\/\/phys.org\/tags\/mouse\/\" rel=\"tag\" class=\"\">mouse<\/a> blastocyst.<\/p>\n<p>The protocol outlining how to do that has now been published in <i>Nature Protocols<\/i> by the UB scientists. They were invited to publish it because of the significant interest generated by the team\u2019s initial publication describing their breakthrough last May.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A year after University at Buffalo scientists demonstrated that it was possible to produce millions of mature human cells in a mouse embryo, they have published a detailed description of the method so that other laboratories can do it, too. The ability to produce millions of mature human cells in a living organism, called a [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1522],"tags":[],"class_list":["post-124574","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-innovation"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/124574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=124574"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/124574\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=124574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=124574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=124574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}