{"id":123420,"date":"2021-06-04T16:55:00","date_gmt":"2021-06-04T23:55:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/06\/sonothermogenetics-for-noninvasive-and-cell-type-specific-deep-brain-neuromodulation"},"modified":"2021-06-04T16:55:00","modified_gmt":"2021-06-04T23:55:00","slug":"sonothermogenetics-for-noninvasive-and-cell-type-specific-deep-brain-neuromodulation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/06\/sonothermogenetics-for-noninvasive-and-cell-type-specific-deep-brain-neuromodulation","title":{"rendered":"Sonothermogenetics for noninvasive and cell-type specific deep brain neuromodulation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/sonothermogenetics-for-noninvasive-and-cell-type-specific-deep-brain-neuromodulation2.jpg\"><\/a><\/p>\n<p>Critical advances in the investigation of brain functions and treatment of brain disorders are hindered by our inability to selectively target neurons in a noninvasive manner in the deep brain.<\/p>\n<p>This study aimed to develop sonothermogenetics for noninvasive, deep-penetrating, and cell-type-specific neuromodulation by combining a thermosensitive ion channel TRPV1 with focused ultrasound (FUS)-induced brief, non-noxious thermal effect.<\/p>\n<p>The sensitivity of TRPV1 to FUS sonication was evaluated <em><i>in vitro<\/i><\/em>. It was followed by <em><i>in vivo<\/i><\/em> assessment of sonothermogenetics in the activation of genetically defined neurons in the mouse brain by two-photon calcium imaging. Behavioral response evoked by sonothermogenetic stimulation at a deep brain target was recorded in freely moving mice. Immunohistochemistry staining of <em><i>ex vivo<\/i><\/em> brain slices was performed to evaluate the safety of FUS sonication.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Critical advances in the investigation of brain functions and treatment of brain disorders are hindered by our inability to selectively target neurons in a noninvasive manner in the deep brain. This study aimed to develop sonothermogenetics for noninvasive, deep-penetrating, and cell-type-specific neuromodulation by combining a thermosensitive ion channel TRPV1 with focused ultrasound (FUS)-induced brief, non-noxious [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,412,47],"tags":[],"class_list":["post-123420","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/123420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=123420"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/123420\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=123420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=123420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=123420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}