{"id":123293,"date":"2021-06-02T08:22:21","date_gmt":"2021-06-02T15:22:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/06\/evidence-of-sleep-dependent-brain-activity-in-clearing-toxic-proteins-and-preventing-alzheimers-disease"},"modified":"2021-06-02T08:22:21","modified_gmt":"2021-06-02T15:22:21","slug":"evidence-of-sleep-dependent-brain-activity-in-clearing-toxic-proteins-and-preventing-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/06\/evidence-of-sleep-dependent-brain-activity-in-clearing-toxic-proteins-and-preventing-alzheimers-disease","title":{"rendered":"Evidence of Sleep-Dependent Brain Activity in Clearing Toxic Proteins and Preventing Alzheimer\u2019s Disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/evidence-of-sleep-dependent-brain-activity-in-clearing-toxic-proteins-and-preventing-alzheimers-disease.gif\"><\/a><\/p>\n<p><strong>Global brain activity seen on fMRI, and its connection with cerebrospinal fluid flow weaker in brains of individuals with Alzheimer\u2019s disease risk or related toxin buildup.<\/strong><\/p>\n<p>Evidence of sleep-dependent low-frequency (0.1 Hz) global brain activity in the clearance of Alzheimer\u2019s disease-related toxin buildup is presented in research published today (June 1, 2021) in the open access journal PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients.<\/p>\n<p>The development of Alzheimer\u2019s disease is believed to be driven by the buildup of the toxic proteins amyloid-\u03b2 and tau in the brain. The brain\u2019s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cerebrospinal fluid flow essential for the glymphatic system.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Global brain activity seen on fMRI, and its connection with cerebrospinal fluid flow weaker in brains of individuals with Alzheimer\u2019s disease risk or related toxin buildup. Evidence of sleep-dependent low-frequency (0.1 Hz) global brain activity in the clearance of Alzheimer\u2019s disease-related toxin buildup is presented in research published today (June 1, 2021) in the open [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-123293","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/123293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=123293"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/123293\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=123293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=123293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=123293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}