{"id":123259,"date":"2021-06-01T11:22:39","date_gmt":"2021-06-01T18:22:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/06\/whos-to-die-and-whos-to-live-mechanical-cue-is-at-the-origin-of-cell-death-decision"},"modified":"2021-06-01T11:22:39","modified_gmt":"2021-06-01T18:22:39","slug":"whos-to-die-and-whos-to-live-mechanical-cue-is-at-the-origin-of-cell-death-decision","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/06\/whos-to-die-and-whos-to-live-mechanical-cue-is-at-the-origin-of-cell-death-decision","title":{"rendered":"Who\u2019s to Die and Who\u2019s to Live: Mechanical Cue Is at the Origin of Cell Death Decision"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/whos-to-die-and-whos-to-live-mechanical-cue-is-at-the-origin-of-cell-death-decision2.jpg\"><\/a><\/p>\n<p><b>Hydraulic Instability Decides Who\u2019s to Die and Who\u2019s to Live<\/b><\/p>\n<p>In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode <em>Caenorhabditis<\/em><em> elegans<\/em>, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs and sperm. These cells are arranged around a central cytoplasmic \u201ccorridor\u201d and exchange cytoplasmic material fostering cell growth, and ultimately produce oocytes ready to be fertilized.<\/p>\n<p>In past studies, researchers have found that <em>C. elegans<\/em> gonads generate more germ cells than needed and that only half of them grow to become oocytes, while the rest shrinks and die by physiological apoptosis, a programmed cell death that occurs in multicellular organisms. Now, scientists from the Biotechnology Center of the TU Dresden (BIOTEC), the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), the Cluster of Excellence Physics of Life (PoL) at the TU Dresden, the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), the Flatiron Institute, NY, and the University of California, Berkeley, found evidence to answer the question of what triggers this cell fate decision between life and death in the germline.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hydraulic Instability Decides Who\u2019s to Die and Who\u2019s to Live In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode Caenorhabditis elegans, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-123259","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/123259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=123259"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/123259\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=123259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=123259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=123259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}