{"id":123188,"date":"2021-05-30T05:22:38","date_gmt":"2021-05-30T12:22:38","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/05\/high-fgf21-low-insulin-and-glucose-a-pro-longevity-strategy"},"modified":"2021-05-30T05:22:38","modified_gmt":"2021-05-30T12:22:38","slug":"high-fgf21-low-insulin-and-glucose-a-pro-longevity-strategy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/05\/high-fgf21-low-insulin-and-glucose-a-pro-longevity-strategy","title":{"rendered":"High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/NreBsyaj0l0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Papers referenced in the video:<\/p>\n<p>FGF21 and Chronic Kidney Disease: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S002604952100038X\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S002604952100038X<\/a><\/p>\n<p>The starvation hormone, fibroblast growth factor-21, extends lifespan in mice:<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3466591\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3466591\/<\/a><\/p>\n<p>Inhibition of growth hormone signaling by the fasting-induced hormone FGF21:<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18585098\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/18585098\/<\/a><\/p>\n<p>Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice:<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32877690\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32877690\/<\/a><\/p>\n<p>Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression:<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2021\/05\/high-fgf21-low-insulin-and-glucose-a-pro-longevity-strategy\">Continue reading \u201cHigh FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Papers referenced in the video: FGF21 and Chronic Kidney Disease: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S002604952100038X The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3466591\/ Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https:\/\/pubmed.ncbi.nlm.nih.gov\/18585098\/ Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https:\/\/pubmed.ncbi.nlm.nih.gov\/32877690\/ Berberine ameliorates cellular senescence and extends the lifespan of [\u2026]<\/p>\n","protected":false},"author":587,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-123188","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/123188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/587"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=123188"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/123188\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=123188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=123188"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=123188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}