{"id":122977,"date":"2021-05-24T16:36:28","date_gmt":"2021-05-24T23:36:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/05\/antibiofilm-and-antivirulence-potential-of-silver-nanoparticles-against-multidrug-resistant-acinetobacter-baumannii"},"modified":"2021-05-24T16:36:28","modified_gmt":"2021-05-24T23:36:28","slug":"antibiofilm-and-antivirulence-potential-of-silver-nanoparticles-against-multidrug-resistant-acinetobacter-baumannii","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/05\/antibiofilm-and-antivirulence-potential-of-silver-nanoparticles-against-multidrug-resistant-acinetobacter-baumannii","title":{"rendered":"Antibiofilm and antivirulence potential of silver nanoparticles against multidrug-resistant Acinetobacter baumannii"},"content":{"rendered":"

<\/a><\/p>\n

The adhesion and colonization or biofilm formation include primary stage in bacterial infections. Major adhesion virulence factors in this step include type I fimbriae (FimH<\/i>) and pilli structures for attachment to the host cells7<\/a>,8<\/a><\/sup>. Furthermore, numerous bacteria secrete toxins and extracellular enzymes which play a crucial role in the apoptosis or necrosis of epithelial cells or immunocytes. Various virulence factors of A. baumannii<\/i><\/i> such as adhesins genes like kpsMII<\/i> (group 2 capsule synthesis) and fimH<\/i>, tratT<\/i> (serum resistance associated), fyuA<\/i> (yersiniabactin receptor) and iutA<\/i> (aerobactin receptor) have been investigated previously9<\/a>,10<\/a><\/sup>. An important polysaccharide for biofilm formation is encoded by pgaABCD<\/i> locus11<\/a><\/sup>. Biofilm production is a strategy to escape from harsh conditions and immune responses, hence play as reservoirs for drug-resistant systemic infections. Biofilm-producing A. baumannii<\/i><\/i> has been isolated from several infectious origins such as pneumonia and devise-associated infections. Bacterial within biofilm can resist significantly more against antibiotics compared to planktonic mode of growth12<\/a><\/sup>. Hence, biofilm-mediated infections are in relapse more frequently13<\/a><\/sup>.<\/p>\n

Therefore, there is an urgent need to enhance the effects of antimicrobials against pathogenic bacteria. In recent years, interest has enhanced towards application of nanoparticles as therapeutic regimens14<\/a>,15<\/a>,16<\/a>,17<\/a>,18<\/a>,19<\/a>,20<\/a>,21<\/a><\/sup>. Silver nanoparticles (AgNPs), which have low toxicity in ecosystems and have high rate of surface capacity, can inhibit accumulation of biofilm materials responsible for evasion and protection22<\/a>,23<\/a>,24<\/a><\/sup>.<\/p>\n

The aim of this study was to isolate A. baumannii<\/i><\/i> from wound infections, determine their resistance and virulence profile, and assess the impact of AgNPs on the bacterial growth, virulence and biofilm-related gene expressions in the isolated strains.<\/p>\n","protected":false},"excerpt":{"rendered":"

The adhesion and colonization or biofilm formation include primary stage in bacterial infections. Major adhesion virulence factors in this step include type I fimbriae (FimH) and pilli structures for attachment to the host cells7,8. Furthermore, numerous bacteria secrete toxins and extracellular enzymes which play a crucial role in the apoptosis or necrosis of epithelial cells [\u2026]<\/p>\n","protected":false},"author":630,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4],"tags":[],"class_list":["post-122977","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/630"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=122977"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122977\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=122977"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=122977"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=122977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}