{"id":122744,"date":"2021-05-20T17:23:34","date_gmt":"2021-05-21T00:23:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/05\/dr-morten-scheibye-knudsen-university-of-copenhagen-aging-dna-repair-and-clinical-innovation"},"modified":"2021-05-20T17:23:34","modified_gmt":"2021-05-21T00:23:34","slug":"dr-morten-scheibye-knudsen-university-of-copenhagen-aging-dna-repair-and-clinical-innovation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/05\/dr-morten-scheibye-knudsen-university-of-copenhagen-aging-dna-repair-and-clinical-innovation","title":{"rendered":"Dr. Morten Scheibye-Knudsen \u2014 University of Copenhagen \u2014 Aging, DNA Repair, And Clinical Innovation"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/rgHtQoOgFiI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Aging, DNA Repair, And Clinical Innovation \u2014 Dr. Morten Scheibye-Knudsen \u2014 University of Copenhagen.<\/p>\n<hr>\n<p>Dr. Morten Scheibye-Knudsen is an Associate Professor at the Department of Cellular and Molecular Medicine, and at the Center for Healthy Aging (CEHA), at the University of Copenhagen.<\/p>\n<p>Dr. Scheibye-Knudsen did his MD at the University of Copenhagen and worked briefly as a physician in Denmark and Greenland before turning to science. He did his post-doctoral fellowship at Vilhelm Bohr\u2019s lab at the National Institute on Aging, National Institutes of Health, USA, where he utilized state-of-the art approaches to understand how DNA damage contributes to aging, discovering that neurodegeneration in several premature aging diseases is partly caused by hyperactivation of a DNA damage responsive enzyme called polyADP-ribose polymerase 1 (PARP1). This activation leads to loss of vital metabolites such as Nicotinamide Adenine Dinucleotide (NAD+) and acetyl-CoA. Importantly, this discovery facilitated the realization that we can intervene in the aging process by inhibiting PARP1, augmenting NAD+ levels and increasing acetyl-CoA.<\/p>\n<p>In his own lab Dr. Scheibye-Knudsen continues to focus on understanding aging by combining machine learning based approaches with wet-lab analyses with the goal of developing interventions for age-associated diseases and perhaps aging itself.<\/p>\n<p>Dr. Scheibye-Knudsen is Chief Editor, Frontiers in Aging, and an Advisory Board Member of the Longevity Vision Fund and Molecule Protocol.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2021\/05\/dr-morten-scheibye-knudsen-university-of-copenhagen-aging-dna-repair-and-clinical-innovation\">Continue reading \u201cDr. Morten Scheibye-Knudsen \u2014 University of Copenhagen \u2014 Aging, DNA Repair, And Clinical Innovation\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aging, DNA Repair, And Clinical Innovation \u2014 Dr. Morten Scheibye-Knudsen \u2014 University of Copenhagen. Dr. Morten Scheibye-Knudsen is an Associate Professor at the Department of Cellular and Molecular Medicine, and at the Center for Healthy Aging (CEHA), at the University of Copenhagen. Dr. Scheibye-Knudsen did his MD at the University of Copenhagen and worked briefly [\u2026]<\/p>\n","protected":false},"author":400,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,6],"tags":[],"class_list":["post-122744","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/400"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=122744"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122744\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=122744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=122744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=122744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}