{"id":122700,"date":"2021-05-19T06:22:19","date_gmt":"2021-05-19T13:22:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/05\/eating-a-western-diet-impairs-the-immune-system-in-the-gut-may-increase-risk-of-inflammation-infection"},"modified":"2021-05-19T06:22:19","modified_gmt":"2021-05-19T13:22:19","slug":"eating-a-western-diet-impairs-the-immune-system-in-the-gut-may-increase-risk-of-inflammation-infection","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/05\/eating-a-western-diet-impairs-the-immune-system-in-the-gut-may-increase-risk-of-inflammation-infection","title":{"rendered":"Eating a Western Diet Impairs the Immune System in the Gut \u2013 May Increase Risk of Inflammation, Infection"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/eating-a-western-diet-impairs-the-immune-system-in-the-gut-may-increase-risk-of-inflammation-infection3.jpg\"><\/a><\/p>\n<p>\u201cThis was a short-term experiment, just eight weeks,\u201d Liu said. \u201cIn people, obesity doesn\u2019t occur overnight or even in eight weeks. People have a suboptimal lifestyle for 20, 30 years before they become obese. It\u2019s possible that if you have Western diet for so long, you cross a point of no return and your Paneth cells don\u2019t recover even if you change your diet. We\u2019d need to do more research before we can say whether this process is reversible in people.\u201d<\/p>\n<hr>\n<p>Eating a Western diet impairs the immune system in the gut in ways that could increase risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic.<\/p>\n<p>The study, in mice and people, showed that a diet high in sugar and fat causes damage to Paneth cells, immune cells in the gut that help keep inflammation in check. When Paneth cells aren\u2019t functioning properly, the gut immune system is excessively prone to inflammation, putting people at risk of inflammatory bowel disease and undermining effective control of disease-causing microbes. The findings, published today (May 18, 2021) in <em>Cell Host &amp; Microbe<\/em>, open up new approaches to regulating gut immunity by restoring normal Paneth cell function.<\/p>\n<p>\u201cInflammatory bowel disease has historically been a problem primarily in Western countries such as the U.S., but it\u2019s becoming more common globally as more and more people adopt Western lifestyles,\u201d said lead author Ta-Chiang Liu, MD, PhD, an associate professor of pathology &amp; immunology at Washington University. \u201cOur research showed that long-term consumption of a Western-style diet high in fat and sugar impairs the function of immune cells in the gut in ways that could promote inflammatory bowel disease or increase the risk of intestinal infections.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cThis was a short-term experiment, just eight weeks,\u201d Liu said. \u201cIn people, obesity doesn\u2019t occur overnight or even in eight weeks. People have a suboptimal lifestyle for 20, 30 years before they become obese. It\u2019s possible that if you have Western diet for so long, you cross a point of no return and your Paneth [\u2026]<\/p>\n","protected":false},"author":621,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-122700","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/621"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=122700"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122700\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=122700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=122700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=122700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}