{"id":122661,"date":"2021-05-17T14:25:25","date_gmt":"2021-05-17T21:25:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/05\/creating-a-safe-car-t-cell-therapy-to-fight-solid-tumors-in-children"},"modified":"2021-05-17T14:25:25","modified_gmt":"2021-05-17T21:25:25","slug":"creating-a-safe-car-t-cell-therapy-to-fight-solid-tumors-in-children","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/05\/creating-a-safe-car-t-cell-therapy-to-fight-solid-tumors-in-children","title":{"rendered":"Creating a safe CAR T-Cell therapy to fight solid tumors in children"},"content":{"rendered":"<p>Scientists modify CAR T-Cell therapy, making it more effective and less toxic, for possible use in solid tumors such as neuroblastoma.<\/p>\n<hr>\n<p>Chimeric Antigen Receptor T-cell therapy \u2014 CAR T \u2014 has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma. Preclinical studies using certain CAR T against neuroblastoma revealed toxic effects. Now, a group of scientists at Children\u2019s Hospital Los Angeles have developed a modified version of CAR T that shows promise in targeting neuroblastoma, spares healthy brain tissue and more effectively kills cancer cells. Their study was published today in <em>Nature Communications<\/em>. While this work is in the preclinical phase, it reveals potential for lifesaving treatment in children and adults with solid tumors.<\/p>\n<p>Shahab Asgharzadeh, MD, a physician scientist at the Cancer and Blood Disease Institute of CHLA, is working to improve the lifesaving CAR T-cell therapy, in which scientists take a patient\u2019s own immune system T-cells and engineer them to recognize and destroy cancer cells.<\/p>\n<p>\u201cThe CAR T therapy works in leukemia,\u201d he says, \u201cby targeting a unique protein (or antigen) on the surface of leukemia cells. When the treatment is given, leukemia cells are killed. CAR T turns the patient\u2019s immune system into a powerful and targeted cancer-killer in patients with leukemia. This antigen is also on normal B cells in the blood, but this side effect can be treated medically.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists modify CAR T-Cell therapy, making it more effective and less toxic, for possible use in solid tumors such as neuroblastoma. Chimeric Antigen Receptor T-cell therapy \u2014 CAR T \u2014 has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma. Preclinical studies using certain [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-122661","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=122661"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122661\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=122661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=122661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=122661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}