{"id":122279,"date":"2021-05-05T08:22:29","date_gmt":"2021-05-05T15:22:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/05\/startup-sets-out-to-tackle-the-gene-therapy-manufacturing-crisis"},"modified":"2021-05-05T08:22:29","modified_gmt":"2021-05-05T15:22:29","slug":"startup-sets-out-to-tackle-the-gene-therapy-manufacturing-crisis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/05\/startup-sets-out-to-tackle-the-gene-therapy-manufacturing-crisis","title":{"rendered":"Startup sets out to tackle the gene therapy manufacturing crisis"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/startup-sets-out-to-tackle-the-gene-therapy-manufacturing-crisis2.jpg\"><\/a><\/p>\n<p>Genetic treatments are difficult to produce without facilities.<\/p>\n<hr>\n<p>Af\u00adter Kel\u00adli Lug\u00adin\u00adbuhl fin\u00adished her PhD, her ad\u00advi\u00adsor, Duke bio\u00adengi\u00adneer and Phase\u00adBio co-founder Ashutosh Chilkoti, sat her down and asked if she want\u00aded to launch and then run a com\u00adpa\u00adny. Chilkoti had a once-ob\u00adscure tech\u00adnol\u00ado\u00adgy he and the ven\u00adture cap\u00adi\u00adtal\u00adist Joe McMa\u00adhon thought could form the ba\u00adsis of his sec\u00adond com\u00adpa\u00adny and fi\u00adnal\u00adly pay huge div\u00adi\u00addends. Lug\u00adin\u00adbuhl knew the tech from years in his lab and was al\u00adready look\u00ading for biotech jobs. It all added up.<\/p>\n<p>Three years, some strate\u00adgiz\u00ading, and 10 or so pitch meet\u00adings lat\u00ader, the trio is launch\u00ading Isol\u00adere Bio, with $7 mil\u00adlion in seed fund\u00ading led by North\u00adpond Ven\u00adtures and tech\u00adnol\u00ado\u00adgy they be\u00adlieve can al\u00adlow gene ther\u00ada\u00adpy com\u00adpa\u00adnies to vast\u00adly in\u00adcrease the num\u00adber of dos\u00ades they can pro\u00adduce. It\u2019s one po\u00adten\u00adtial so\u00adlu\u00adtion to a slow-boil\u00ading cri\u00adsis that has be\u00adcome in\u00adcreas\u00ading\u00adly acute, as new com\u00adpa\u00adnies strug\u00adgle to get the ma\u00adte\u00adri\u00adals they need for tri\u00adals and some com\u00admon dis\u00adeases re\u00admain the\u00ado\u00adret\u00adi\u00adcal\u00adly un\u00adfix\u00adable by gene ther\u00ada\u00adpy, be\u00adcause com\u00adpa\u00adnies would nev\u00ader be able to make enough dos\u00ades for that many patients.<\/p>\n<p>The prob\u00adlem is par\u00adtial\u00adly that the fa\u00adcil\u00adi\u00adties don\u2019t yet ex\u00adist to pro\u00adduce this much of gene ther\u00ada\u00adpy. Ex\u00adperts, how\u00adev\u00ader, al\u00adso point to an\u00adti\u00adquat\u00aded man\u00adu\u00adfac\u00adtur\u00ading processes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genetic treatments are difficult to produce without facilities. Af\u00adter Kel\u00adli Lug\u00adin\u00adbuhl fin\u00adished her PhD, her ad\u00advi\u00adsor, Duke bio\u00adengi\u00adneer and Phase\u00adBio co-founder Ashutosh Chilkoti, sat her down and asked if she want\u00aded to launch and then run a com\u00adpa\u00adny. Chilkoti had a once-ob\u00adscure tech\u00adnol\u00ado\u00adgy he and the ven\u00adture cap\u00adi\u00adtal\u00adist Joe McMa\u00adhon thought could form the basis [\u2026]<\/p>\n","protected":false},"author":621,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1878,412],"tags":[],"class_list":["post-122279","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-employment","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/621"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=122279"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/122279\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=122279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=122279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=122279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}