{"id":121776,"date":"2021-04-20T18:22:55","date_gmt":"2021-04-21T01:22:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/04\/bacterial-molecule-can-slow-sjogrens-progression-preclinical-study-suggests"},"modified":"2021-04-20T18:22:55","modified_gmt":"2021-04-21T01:22:55","slug":"bacterial-molecule-can-slow-sjogrens-progression-preclinical-study-suggests","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/04\/bacterial-molecule-can-slow-sjogrens-progression-preclinical-study-suggests","title":{"rendered":"Bacterial Molecule Can Slow Sj\u00f6gren\u2019s Progression, Preclinical Study Suggests"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/bacterial-molecule-can-slow-sjogrens-progression-preclinical-study-suggests2.jpg\"><\/a><\/p>\n<p>Oral treatment with a bacterial protein known as colonization factor antigen I (CFA\/I) fimbriae, from Escherichia coli bacteria, has been shown to protect against several autoimmune diseases, including arthritis and type 1 diabetes. Another bacteria, called Lactococcus lactis, was recently adapted to express CFA\/I fimbriae. These bacteria were shown to effectively suppress inflammation by the induction of regulatory T-cells (Tregs) \u2014 which are negative regulators of the immune system, meaning they work to shut down excessive inflammatory responses.<\/p>\n<hr>\n<p>Oral treatment with a molecule produced by bacteria, called colonization factor antigen I, can reduce or halt the progression of <a href=\"https:\/\/sjogrenssyndromenews.com\/2019\/08\/23\/faqs-in-sjogrens-syndrome\/\">Sj\u00f6gren\u2019s syndrome<\/a>, a mouse study suggests.<\/p>\n<p>Researchers believe these findings provide the basis for future testing in patients with Sj\u00f6gren\u2019s.<\/p>\n<p>The study, \u201c<a href=\"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-021-02475-1\">Stimulation of regulatory T cells with <em>Lactococcus lactis<\/em> expressing enterotoxigenic <em>E. coli<\/em> colonization factor antigen 1 retains salivary flow in a genetic model of Sj\u00f6gren\u2019s syndrome<\/a>,\u201d was published in the journal <a href=\"https:\/\/arthritis-research.biomedcentral.com\/\"><em>Arthritis Research &amp; Therapy<\/em><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oral treatment with a bacterial protein known as colonization factor antigen I (CFA\/I) fimbriae, from Escherichia coli bacteria, has been shown to protect against several autoimmune diseases, including arthritis and type 1 diabetes. Another bacteria, called Lactococcus lactis, was recently adapted to express CFA\/I fimbriae. These bacteria were shown to effectively suppress inflammation by the [\u2026]<\/p>\n","protected":false},"author":621,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-121776","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/121776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/621"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=121776"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/121776\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=121776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=121776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=121776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}