{"id":121174,"date":"2021-04-02T12:22:28","date_gmt":"2021-04-02T19:22:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/04\/the-first-non-invasive-biomarker-to-track-and-verify-efficacy-of-senolytic-drugs"},"modified":"2021-04-02T12:22:28","modified_gmt":"2021-04-02T19:22:28","slug":"the-first-non-invasive-biomarker-to-track-and-verify-efficacy-of-senolytic-drugs","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/04\/the-first-non-invasive-biomarker-to-track-and-verify-efficacy-of-senolytic-drugs","title":{"rendered":"The first non-invasive biomarker to track and verify efficacy of senolytic drugs"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-first-non-invasive-biomarker-to-track-and-verify-efficacy-of-senolytic-drugs2.jpg\"><\/a><\/p>\n<p>Buck Institute researchers have discovered and are developing a novel, non-invasive biomarker test that can be used to measure and track performance of senolytics: a class of drugs that selectively eliminate senescent cells. The discovery is expected to play a major role in efforts to develop treatments that would battle a myriad of chronic age-related conditions that range from arthritis to lung disease to Alzheimer\u2019s disease and glaucoma. This biomarker is a unique signaling lipid metabolite, normally exclusively intracellular, but is released when senescent cells are forced to die. This metabolite is detectible in blood and urine, making non-invasive testing possible. With a growing list of senolytic drugs in development, detecting this metabolite via a companion test could verify performance of senolytic candidates.<\/p>\n<p>\u201cThe list of age-related diseases definitively linked to cellular <a href=\"https:\/\/medicalxpress.com\/tags\/senescence\/\" rel=\"tag\" class=\"\">senescence<\/a> keeps growing, as does the number of biotech companies racing to develop drugs to eliminate senescent <a href=\"https:\/\/medicalxpress.com\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a>,\u201d said Buck professor Judith Campisi, Ph.D., senior scientist on the study. \u201cWhile the field has never been more promising, the lack of a simple biomarker to measure and track efficacy of these treatments has been a hindrance to progress. We are excited to bring this new biomarker to the field and look forward to it being used in the clinic.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Buck Institute researchers have discovered and are developing a novel, non-invasive biomarker test that can be used to measure and track performance of senolytics: a class of drugs that selectively eliminate senescent cells. The discovery is expected to play a major role in efforts to develop treatments that would battle a myriad of chronic age-related [\u2026]<\/p>\n","protected":false},"author":426,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-121174","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/121174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/426"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=121174"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/121174\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=121174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=121174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=121174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}