{"id":121029,"date":"2021-03-29T12:05:19","date_gmt":"2021-03-29T19:05:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/03\/brain-cell-clusters-grown-in-lab-for-more-than-a-year-mirror-changes-in-a-newborns-brain"},"modified":"2021-03-29T12:05:19","modified_gmt":"2021-03-29T19:05:19","slug":"brain-cell-clusters-grown-in-lab-for-more-than-a-year-mirror-changes-in-a-newborns-brain","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/03\/brain-cell-clusters-grown-in-lab-for-more-than-a-year-mirror-changes-in-a-newborns-brain","title":{"rendered":"Brain cell clusters, grown in lab for more than a year, mirror changes in a newborn\u2019s brain"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brain-cell-clusters-grown-in-lab-for-more-than-a-year-mirror-changes-in-a-newborns-brain3.jpg\"><\/a><\/p>\n<p>Stanford University neurobiologist Sergiu Pa\u0219ca has been making brain organoids for about 10 years, and his team has learned that some of these tissue blobs can thrive in a dish for years. In the new study, they teamed up with neurogeneticist Daniel Geschwind and colleagues at the University of California, Los Angeles (UCLA), to analyze how the blobs changed over their life spans\u2026<\/p>\n<p>\u2026They noticed that when an organoid reached 250 to 300 days old\u2014roughly 9 months\u2014its gene expression shifted to more closely resemble that of cells from human brains soon after birth. The cells\u2019 patterns of methylation\u2014chemical tags that can affix to DNA and influence gene activity\u2014also corresponded to increasingly mature human brain cells as the organoids aged, the team reports today in Nature Neuroscience.<\/p>\n<hr>\n<p>Organoids develop genetic signatures of postnatal brains, possibly broadening their use as disease models.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stanford University neurobiologist Sergiu Pa\u0219ca has been making brain organoids for about 10 years, and his team has learned that some of these tissue blobs can thrive in a dish for years. In the new study, they teamed up with neurogeneticist Daniel Geschwind and colleagues at the University of California, Los Angeles (UCLA), to analyze [\u2026]<\/p>\n","protected":false},"author":621,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,412,47],"tags":[],"class_list":["post-121029","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/121029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/621"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=121029"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/121029\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=121029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=121029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=121029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}