{"id":118109,"date":"2021-01-06T14:23:53","date_gmt":"2021-01-06T22:23:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2021\/01\/incredible-gene-editing-result-in-mice-inspires-plans-to-treat-premature-aging-syndrome-in-children"},"modified":"2021-01-06T14:23:53","modified_gmt":"2021-01-06T22:23:53","slug":"incredible-gene-editing-result-in-mice-inspires-plans-to-treat-premature-aging-syndrome-in-children","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2021\/01\/incredible-gene-editing-result-in-mice-inspires-plans-to-treat-premature-aging-syndrome-in-children","title":{"rendered":"\u2018Incredible\u2019 gene-editing result in mice inspires plans to treat premature-aging syndrome in children"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/veuArNd4-mU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>One mouse is hunched over, graying, and barely moves at 7 months old. Others, at 11 months, have sleek black coats and run around. The videos and other results from a new study have inspired hope for treating children born with progeria, a rare, fatal, genetic disease that causes symptoms much like early aging. In mice with a progeria-causing mutation, a cousin of the celebrated genome editor known as CRISPR corrected the DNA mistake, preventing the heart damage typical of the disease, a research team reports today in. Treated mice lived about 500 days, more than twice as long as untreated animals.<\/p>\n<p>\u201cThe outcome is incredible,\u201d says gene-therapy researcher Guangping Gao of the University of Massachusetts, who was not involved with the study.<\/p>\n<p>Although the developers of the progeria therapy aim to improve it, they are also taking steps toward testing the current version in affected children, and some other scientists endorse a rush. The mouse results are \u201cbeyond anyone\u2019s wildest expectations,\u201d says Fyodor Urnov, a gene-editing researcher at the University of California, Berkeley. \u201cThe new data are an imperative to treat a child with progeria \u2026 and do so in the next 3 years.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One mouse is hunched over, graying, and barely moves at 7 months old. Others, at 11 months, have sleek black coats and run around. The videos and other results from a new study have inspired hope for treating children born with progeria, a rare, fatal, genetic disease that causes symptoms much like early aging. In [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-118109","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/118109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=118109"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/118109\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=118109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=118109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=118109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}