{"id":114819,"date":"2020-10-21T17:25:20","date_gmt":"2020-10-22T00:25:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/10\/new-vaccine-could-help-halt-alzheimers-progression-preclinical-study-finds"},"modified":"2020-10-21T17:25:20","modified_gmt":"2020-10-22T00:25:20","slug":"new-vaccine-could-help-halt-alzheimers-progression-preclinical-study-finds","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/10\/new-vaccine-could-help-halt-alzheimers-progression-preclinical-study-finds","title":{"rendered":"New vaccine could help halt Alzheimer\u2019s progression, preclinical study finds"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-vaccine-could-help-halt-alzheimers-progression-preclinical-study-finds2.jpg\"><\/a><\/p>\n<p>Our immune system\u2019s capacity to mount a well-regulated defense against foreign substances, including toxins, weakens with age and makes vaccines less effective in people over age 65. At the same time, research has shown that immunotherapy targeting neurotoxic forms of the peptide amyloid beta (oligomeric A\u03b2) may halt the progression of Alzheimer\u2019s disease, the most common age-related neurodegenerative disease.<\/p>\n<p>A team led by Chuanhai Cao, Ph.D., of the University of South Florida Health (USF Health), has focused on overcoming, in those with impaired immunity, excess inflammation and other complications that interfere with development of a therapeutic Alzheimer\u2019s vaccine.<\/p>\n<p>Now, a <a href=\"https:\/\/medicalxpress.com\/tags\/preclinical+study\/\" rel=\"tag\" class=\"\">preclinical study<\/a> by Dr. Cao and colleagues indicates that an antigen-presenting dendritic vaccine with a specific antibody response to oligomeric A\u03b2 may be safer and offer clinical benefit in treating Alzheimer\u2019s disease. The vaccine, called E22W42 DC, uses immune <a href=\"https:\/\/medicalxpress.com\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a> known as dendritic cells (DC) loaded with a modified A\u03b2 peptide as the antigen.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our immune system\u2019s capacity to mount a well-regulated defense against foreign substances, including toxins, weakens with age and makes vaccines less effective in people over age 65. At the same time, research has shown that immunotherapy targeting neurotoxic forms of the peptide amyloid beta (oligomeric A\u03b2) may halt the progression of Alzheimer\u2019s disease, the most [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-114819","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/114819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=114819"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/114819\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=114819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=114819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=114819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}