{"id":113562,"date":"2020-09-29T11:22:29","date_gmt":"2020-09-29T18:22:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/09\/blocking-enzymes-self-destruction-process-may-mitigate-age-related-diseases"},"modified":"2020-09-29T11:22:29","modified_gmt":"2020-09-29T18:22:29","slug":"blocking-enzymes-self-destruction-process-may-mitigate-age-related-diseases","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/09\/blocking-enzymes-self-destruction-process-may-mitigate-age-related-diseases","title":{"rendered":"Blocking enzyme\u2019s self-destruction process may mitigate age-related diseases"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/blocking-enzymes-self-destruction-process-may-mitigate-age-related-diseases2.jpg\"><\/a><\/p>\n<p>Stopping the cannibalistic behavior of a well-studied enzyme could be the key to new drugs to fight age-related diseases, according to a new study published online in <i>Nature Cell Biology<\/i>. For the first time, researchers in the Perelman School of Medicine at the University of Pennsylvania show how the self-eating cellular process known as autophagy is causing the SIRT1 enzyme, long known to play a role in longevity, to degrade over time in cells and tissue in mice. Identifying an enzymatic target is an important step that may lead to new or modified existing therapeutics.<\/p>\n<p>\u201cBlocking this pathway could be another potential approach to restore the level of SIRT1 in patients to help treat or prevent age-related organ and immune system decline,\u201d said first author Lu Wang, Ph.D., a postdoctoral researcher in the lab of Shelly Berger, Ph.D., a professor of Cell and Developmental Biology in the Perelman School of Medicine and a professor of Biology in the School of Arts and Sciences at Penn. Berger also serves as senior author on the paper.<\/p>\n<p>\u201cThe findings may be of most interest to the immune aging field, as autophagy\u2019s role in SIRT1 in immune <a href=\"https:\/\/medicalxpress.com\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a> is a concept that hasn\u2019t been shown before,\u201d Wang added. \u201cExploiting this mechanism presents us with a new possibility of restoring immune function.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stopping the cannibalistic behavior of a well-studied enzyme could be the key to new drugs to fight age-related diseases, according to a new study published online in Nature Cell Biology. For the first time, researchers in the Perelman School of Medicine at the University of Pennsylvania show how the self-eating cellular process known as autophagy [\u2026]<\/p>\n","protected":false},"author":426,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-113562","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/113562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/426"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=113562"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/113562\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=113562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=113562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=113562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}