{"id":112310,"date":"2020-09-02T07:22:37","date_gmt":"2020-09-02T14:22:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/09\/humoral-immune-response-to-sars-cov-2-in-iceland"},"modified":"2020-09-02T07:22:37","modified_gmt":"2020-09-02T14:22:37","slug":"humoral-immune-response-to-sars-cov-2-in-iceland","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/09\/humoral-immune-response-to-sars-cov-2-in-iceland","title":{"rendered":"Humoral Immune Response to SARS-CoV-2 in Iceland"},"content":{"rendered":"

<\/a><\/p>\n

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (Covid-19), emerged in December 2019.1<\/a><\/sup> Seroconversion of most patients with Covid-19 occurs between 7 and 14 days after diagnosis.2,3<\/a><\/sup> A study of 61,000 persons in Spain showed that 5% of the population had formed antibodies against the spike and nucleoproteins and that approximately one third of infected persons were asymptomatic.4<\/a><\/sup> It was suggested that a substantial fraction of those infected become antibody-negative early in the convalescence period.5<\/a><\/sup> Several studies have reported a higher prevalence4<\/a><\/sup> and levels3,5<\/a><\/sup> of SARS-CoV-2 antibodies in severely ill patients than in those with no or mild symptoms.<\/p>\n

The infection fatality risk of SARS-CoV-2 is difficult to estimate because the total number of diagnosed and undiagnosed cases is needed as the denominator. The infection fatality risk was reported as 0.4% in a small German town after carnival festivities,6<\/a><\/sup> 0.6% on the Diamond Princess cruise ship,7<\/a><\/sup> and 0.66% in China.8<\/a><\/sup><\/p>\n

Well-validated serologic assays for SARS-CoV-2 are urgently needed. Several small comparative studies of commercial SARS-CoV-2 antibody assays have been published.9\u201312<\/a><\/sup> A highly specific assay is required for screening populations with a low seroprevalence, such as that in Iceland.<\/p>\n","protected":false},"excerpt":{"rendered":"

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (Covid-19), emerged in December 2019.1 Seroconversion of most patients with Covid-19 occurs between 7 and 14 days after diagnosis.2,3 A study of 61,000 persons in Spain showed that 5% of the population had formed antibodies against the spike and nucleoproteins and that approximately one [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-112310","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/112310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=112310"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/112310\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=112310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=112310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=112310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}