{"id":111597,"date":"2020-08-19T11:22:36","date_gmt":"2020-08-19T18:22:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/08\/study-finds-cancer-boosting-culprit-that-multiplies-with-age"},"modified":"2020-08-19T11:22:36","modified_gmt":"2020-08-19T18:22:36","slug":"study-finds-cancer-boosting-culprit-that-multiplies-with-age","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/08\/study-finds-cancer-boosting-culprit-that-multiplies-with-age","title":{"rendered":"Study finds cancer-boosting culprit that multiplies with age"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-finds-cancer-boosting-culprit-that-multiplies-with-age2.jpg\"><\/a><\/p>\n<p>\u201cObservations of metastasising cells revealed something intriguing\u2014a high level of something called methylmalonic acid (MMA), a metabolic byproduct that appears to accumulate as we get older.\u201d<\/p>\n<p>\u201cSo how does MMA induce these changes in cancer cells? The key seems to be in a sort of reprogramming that \u201cswitches on\u201d a gene called SOX4.<\/p>\n<p>Prior research has shown SOX4 encourages cancer cells to become more aggressive and prone to metastasis.<\/p>\n<p>To test whether it was indeed SOX4 that was altering the qualities of the cancer cells, the team blocked expression of the gene, and found that MMA no longer appeared to have the same effect.<\/p>\n<p>Blocking SOX4 also stopped the process by which the cancer cells were able to resist two cancer treatments.\u201d<\/p>\n<hr>\n<p>As our bodies convert food into energy, they produce debris that accumulates as we age. New research shows that one of these metabolic throwaways plays a potentially deadly role in the development of cancer.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2020\/08\/study-finds-cancer-boosting-culprit-that-multiplies-with-age\">Continue reading \u201cStudy finds cancer-boosting culprit that multiplies with age\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cObservations of metastasising cells revealed something intriguing\u2014a high level of something called methylmalonic acid (MMA), a metabolic byproduct that appears to accumulate as we get older.\u201d \u201cSo how does MMA induce these changes in cancer cells? The key seems to be in a sort of reprogramming that \u201cswitches on\u201d a gene called SOX4. Prior research [\u2026]<\/p>\n","protected":false},"author":426,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-111597","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/111597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/426"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=111597"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/111597\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=111597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=111597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=111597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}