{"id":110921,"date":"2020-08-05T13:02:57","date_gmt":"2020-08-05T20:02:57","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/08\/researchers-discover-treatment-option-for-rare-genetic-disorder"},"modified":"2020-08-05T13:02:57","modified_gmt":"2020-08-05T20:02:57","slug":"researchers-discover-treatment-option-for-rare-genetic-disorder","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/08\/researchers-discover-treatment-option-for-rare-genetic-disorder","title":{"rendered":"Researchers discover treatment option for rare genetic disorder"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-discover-treatment-option-for-rare-genetic-disorder2.jpg\"><\/a><\/p>\n<p>Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of\u2014and a treatment for\u2014a previously unknown severe auto inflammatory syndrome affecting an 18-year-old girl since infancy.<\/p>\n<p>The technology, tailored to the patient\u2019s own genetic code at a single cell level, helped the researchers characterize an unknown mutation in a gene called JAK1 that caused the patient\u2019s immune system to be permanently turned on, resulting in rashes over much of her skin, growth abnormalities, kidney failure, allergic hypersensitivities, and an unusual inflammatory condition throughout the digestive tract.<\/p>\n<p>The study, led by Dusan Bogunovic, Ph.D., Associate Professor of Microbiology, and Pediatrics, at the Icahn School of Medicine at Mount Sinai, faculty member of The Mindich Child Health and Development Institute and the Precision Immunology Institute at Mount Sinai, and Director of the Center for Inborn Errors of <i>Immunity<\/i>, was published in the August 3 issue of the journal <i>Immunity<\/i>. The discovery points toward new ways to study how genetic diseases manifest and presents a model of personalized diagnosis and treatment for patients with genetic diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of\u2014and a treatment for\u2014a previously unknown severe auto inflammatory syndrome affecting an 18-year-old girl since infancy. The technology, tailored to the patient\u2019s own genetic code at a single cell level, helped the researchers characterize an unknown mutation [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-110921","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/110921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=110921"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/110921\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=110921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=110921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=110921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}