{"id":110788,"date":"2020-08-03T10:22:29","date_gmt":"2020-08-03T17:22:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/08\/silencing-the-sars-cov-2-receptor-with-crispr-and-epigenetic-modifications"},"modified":"2020-08-03T10:22:29","modified_gmt":"2020-08-03T17:22:29","slug":"silencing-the-sars-cov-2-receptor-with-crispr-and-epigenetic-modifications","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/08\/silencing-the-sars-cov-2-receptor-with-crispr-and-epigenetic-modifications","title":{"rendered":"Silencing the SARS-CoV-2 Receptor With CRISPR and Epigenetic Modifications"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/r10Im0mvIH8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p><a href=\"https:\/\/www.embl.it\/research\/unit\/hackett\/\" target=\"_blank\"> The Hackett Group<\/a> at <a href=\"https:\/\/www.embl.it\/index.php\" target=\"_blank\"> EMBL Rome<\/a> explores epigenetics, genome regulation and cell identity. Recently, the scientists developed a novel CRISPR molecular tool for editing the epigenome, enabling transient modifications that can switch certain genes \u201con\u201d and \u201coff\u201d temporarily.<\/p>\n<p>The SARS-CoV-2 virus that has caused the COVID-19 global pandemic makes its way into a host cell via a protein known as ACE2, which is involved in a range of physiological functions in the body.<\/p>\n<p>What happens when you transiently turn \u201coff\u201d the gene that encodes this protein? Can SARS-CoV-2 still enter the cell and cause infection? This is what Hackett and colleagues are currently exploring in animal models, to determine whether epigenetic silencing could be a treatment approach for COVID-19 in humans.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Hackett Group at EMBL Rome explores epigenetics, genome regulation and cell identity. Recently, the scientists developed a novel CRISPR molecular tool for editing the epigenome, enabling transient modifications that can switch certain genes \u201con\u201d and \u201coff\u201d temporarily. The SARS-CoV-2 virus that has caused the COVID-19 global pandemic makes its way into a host cell [\u2026]<\/p>\n","protected":false},"author":575,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-110788","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/110788","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/575"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=110788"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/110788\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=110788"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=110788"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=110788"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}