{"id":110523,"date":"2020-07-27T09:22:28","date_gmt":"2020-07-27T16:22:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/07\/self-eating-stem-cells-may-hold-the-key-to-new-regenerative-therapies"},"modified":"2020-07-27T09:22:28","modified_gmt":"2020-07-27T16:22:28","slug":"self-eating-stem-cells-may-hold-the-key-to-new-regenerative-therapies","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/07\/self-eating-stem-cells-may-hold-the-key-to-new-regenerative-therapies","title":{"rendered":"\u201cSelf-Eating\u201d Stem Cells May Hold the Key to New Regenerative Therapies"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/self-eating-stem-cells-may-hold-the-key-to-new-regenerative-therapies.jpg\"><\/a><\/p>\n<p>The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new <a href=\"https:\/\/doi.org\/10.1126\/science.abb4467\" target=\"_blank\">study<\/a> published online in Science.<\/p>\n<p>Human bodies contain over 200 different types of specialized cells. All of them can be derived from embryonic stem (ES) cells, which relentlessly self-renew while retaining the ability to differentiate into any cell type in adult animals, a state known as pluripotency. Researchers have known that the cells\u2019 metabolism plays a role in this process; however, it wasn\u2019t clear exactly how the cells\u2019 internal wiring works to keep that state and ultimately decide stem cell fate.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new study published online in Science. Human bodies contain over 200 different types of specialized cells. All of [\u2026]<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-110523","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/110523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=110523"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/110523\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=110523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=110523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=110523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}