{"id":110012,"date":"2020-07-16T00:42:17","date_gmt":"2020-07-16T07:42:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/07\/moderna-advancing-covid-19-vaccine-into-phase-iii-after-positive-initial-clinical-results"},"modified":"2020-07-16T00:42:17","modified_gmt":"2020-07-16T07:42:17","slug":"moderna-advancing-covid-19-vaccine-into-phase-iii-after-positive-initial-clinical-results","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/07\/moderna-advancing-covid-19-vaccine-into-phase-iii-after-positive-initial-clinical-results","title":{"rendered":"Moderna Advancing COVID-19 Vaccine into Phase III after Positive Initial Clinical Results"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/moderna-advancing-covid-19-vaccine-into-phase-iii-after-positive-initial-clinical-results.jpg\"><\/a><\/p>\n<p>Moderna, Inc.\u2019s COVID-19 vaccine candidate mRNA-1273 will advance to a 30,000-participant Phase III trial later this month, following publication of additional positive Phase I data from a study led by the National Institutes of Health (NIH)\u2019s National Institute of Allergy and Infectious Diseases (NIAID).<\/p>\n<hr>\n<p>Moderna said its closely-watched COVID-19 vaccine candidate mRNA-1273 will advance to a 30,000-participant Phase III trial later this month, following publication of additional positive Phase I data from a study led by the NIH\u2019s National Institute of Allergy and Infectious Diseases (NIAID).<\/p>\n<p>The Phase III \u201cCOVE\u201d study (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04470427\">NCT04470427<\/a>) is expected to begin registration at study centers nationwide beginning on July 21 with study initiation set for six days later. The primary endpoint of the randomized, 1:1 placebo-controlled trial will be the prevention of symptomatic COVID-19 disease. Key secondary endpoints include prevention of severe COVID-19 disease as defined by the need for hospitalization, and prevention of infection by SARS-CoV-2, Moderna said.<\/p>\n<p>Moderna disclosed plans for the Phase III trial on Clinicaltrials.gov the same day that researchers from NIAID, Moderna, and their clinical research partners reported that mRNA-1273 induced rapid and strong immune responses against SARS-CoV-2, in an interim analysis of results from their Phase I study (NCT04283461).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Moderna, Inc.\u2019s COVID-19 vaccine candidate mRNA-1273 will advance to a 30,000-participant Phase III trial later this month, following publication of additional positive Phase I data from a study led by the National Institutes of Health (NIH)\u2019s National Institute of Allergy and Infectious Diseases (NIAID). Moderna said its closely-watched COVID-19 vaccine candidate mRNA-1273 will advance to [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-110012","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/110012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=110012"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/110012\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=110012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=110012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=110012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}