{"id":109921,"date":"2020-07-14T05:02:52","date_gmt":"2020-07-14T12:02:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/07\/two-genetic-regions-linked-with-severe-covid-19"},"modified":"2020-07-14T05:02:52","modified_gmt":"2020-07-14T12:02:52","slug":"two-genetic-regions-linked-with-severe-covid-19","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/07\/two-genetic-regions-linked-with-severe-covid-19","title":{"rendered":"Two Genetic Regions Linked with Severe COVID-19"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/two-genetic-regions-linked-with-severe-covid-193.jpg\"><\/a><\/p>\n<p>\ud83e\udd14<\/p>\n<p>It\u2019s not yet clear why some people infected with SARS-CoV-2, the virus that causes COVID-19, get really sick, while others have only mild symptoms. There\u2019s some evidence that chronic health conditions\u2014such as hypertension and diabetes can play a role, and scientists know that people\u2019s genes can influence how their bodies react to other viruses. In a preprint posted to medRxiv on June 2, researchers describe a genome-wide association study (GWAS) of from 1,610 hospitalized patients with COVID-19 and 2,205 healthy controls. The authors identified variants in two regions\u2014the locus that encodes blood type and a multi-gene cluster on chromosome 3\u2014that were linked to respiratory failure during SARS-CoV-2 infection.<\/p>\n<hr>\n<p>In a genome-wide association study, variants in both the ABO blood group locus and a cluster of genes on human chromosome 3 are more common among COVID-19 patients with respiratory failure than in the general population.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud83e\udd14 It\u2019s not yet clear why some people infected with SARS-CoV-2, the virus that causes COVID-19, get really sick, while others have only mild symptoms. There\u2019s some evidence that chronic health conditions\u2014such as hypertension and diabetes can play a role, and scientists know that people\u2019s genes can influence how their bodies react to other viruses. [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-109921","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/109921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=109921"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/109921\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=109921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=109921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=109921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}