{"id":109807,"date":"2020-07-12T00:46:34","date_gmt":"2020-07-12T07:46:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/07\/new-crispr-enzyme-mutation-proves-almost-100-times-more-precise"},"modified":"2020-07-12T00:46:34","modified_gmt":"2020-07-12T07:46:34","slug":"new-crispr-enzyme-mutation-proves-almost-100-times-more-precise","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/07\/new-crispr-enzyme-mutation-proves-almost-100-times-more-precise","title":{"rendered":"New CRISPR enzyme mutation proves almost 100 times more precise"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-crispr-enzyme-mutation-proves-almost-100-times-more-precise2.jpg\"><\/a><\/p>\n<p>The <a class=\"\" href=\"https:\/\/newatlas.com\/crispr-trial-underway-vertex-gene-therapy\/58643\/\">CRISPR-Cas9 gene editing system<\/a> is an extremely powerful tool, but there are still a <a class=\"\" href=\"https:\/\/newatlas.com\/crispr-gene-editing-what-causes-failure\/55428\/\">few kinks<\/a> to iron out. One of the main problems is off-target edits, which can have serious consequences. Now, researchers have found a particular mutation of the CRISPR enzyme that\u2019s almost 100 times more precise than the most commonly used one.<\/p>\n<p>CRISPR gene-editing is based on a bacterial defense system, in which the bugs use a particular enzyme to snip out a section of a pathogen\u2019s DNA and store it for future reference. Next time that pathogen is encountered, the system will recognize it and be better equipped to fight it off.<\/p>\n<p>Scientists managed to co-opt this system as a handy genetic engineering tool. CRISPR-Cas9 uses this mechanism to scour a target\u2019s genome for a specific sequence of DNA \u2013 say one that could cause disease \u2013 then cut it out, sometimes replacing it with a more beneficial sequence.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The CRISPR-Cas9 gene editing system is an extremely powerful tool, but there are still a few kinks to iron out. One of the main problems is off-target edits, which can have serious consequences. Now, researchers have found a particular mutation of the CRISPR enzyme that\u2019s almost 100 times more precise than the most commonly used [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-109807","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/109807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=109807"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/109807\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=109807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=109807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=109807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}