{"id":109262,"date":"2020-06-28T20:42:59","date_gmt":"2020-06-29T03:42:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/06\/human-trials-of-plasma-exchange"},"modified":"2020-06-28T20:42:59","modified_gmt":"2020-06-29T03:42:59","slug":"human-trials-of-plasma-exchange","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/06\/human-trials-of-plasma-exchange","title":{"rendered":"Human Trials of Plasma Exchange"},"content":{"rendered":"

<\/a><\/p>\n

Animal experiments demonstrating the anti-aging effects of exchanging young blood plasma for old have been prominent in the last two months. Several groups are saying it\u2019s time to translate their findings into human trials. But I\u2019ve recently learned that others have been doing this for several years. What can we learn from their results to guide the next steps in experimentation?<\/em><\/p>\n

I had never heard of Grifols<\/a>, the Spanish pharmaceutical company that is the world\u2019s largest supplier of albumin. Since 2005<\/a>, Grifols has been quietly funding world leaders in plasma exchange research in humans. Albutein <\/a>\u00ae is their brand-name solution of human albumin.<\/p>\n

Last month, the first results<\/a> of the Grifol\u2019s AMBAR trial were released. (AMBAR stands for A lzheimer\u2019s M odulation B y A lbumin R eplacement). It was a much larger-scale phase 2.5 trial, with 496 subjects recruited from sites in Spain and USA, and treated for 14 months. A single treatment consisted of removing 2.5 to 3 litres of blood (more than half the body\u2019s inventory) and replacing it with Albutein. Patients began with 6 weekly treatments, and thereafter there were 12 monthly smaller plasma replacements (0.7 litres), again with Albutein.<\/p>\n","protected":false},"excerpt":{"rendered":"

Animal experiments demonstrating the anti-aging effects of exchanging young blood plasma for old have been prominent in the last two months. Several groups are saying it\u2019s time to translate their findings into human trials. But I\u2019ve recently learned that others have been doing this for several years. What can we learn from their results to [\u2026]<\/p>\n","protected":false},"author":530,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-109262","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/109262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/530"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=109262"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/109262\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=109262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=109262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=109262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}