{"id":108199,"date":"2020-06-05T08:03:32","date_gmt":"2020-06-05T15:03:32","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/06\/scientists-have-found-a-way-to-shuffle-atoms-to-dramatically-improve-drugs-effectiveness-and-safety"},"modified":"2020-06-05T08:03:32","modified_gmt":"2020-06-05T15:03:32","slug":"scientists-have-found-a-way-to-shuffle-atoms-to-dramatically-improve-drugs-effectiveness-and-safety","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/06\/scientists-have-found-a-way-to-shuffle-atoms-to-dramatically-improve-drugs-effectiveness-and-safety","title":{"rendered":"Scientists Have Found a Way to Shuffle Atoms to Dramatically Improve Drugs\u2019 Effectiveness and Safety"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-have-found-a-way-to-shuffle-atoms-to-dramatically-improve-drugs-effectiveness-and-safety.jpg\"><\/a><\/p>\n<p>Scientists have found a new method to strategically add deuterium to benzene, an aromatic compound commonly found in crude oil. When applied to the active ingredient of drugs to incorporate deuterium, it could dramatically improve the drugs\u2019 efficacy and safety and even introduce new medicines.<\/p>\n<p>To validate the method, which was published in <em>Nature<\/em>, a team led by W. Dean Harman of the University of Virginia worked with Xiaoping Wang at the Oak Ridge National Laboratory\u2019s Spallation Neutron Source. Wang successfully verified the exact position of deuterium atoms that resulted from the selective deuteration of benzene molecules using single crystal neutron diffraction.<\/p>\n<p>\u201cBecause the high sensitivity of neutrons to hydrogen and its deuterium isotope, we were able to quantitatively assign not only the positions of the deuterium atoms at the atomic level, but also determine precisely how many were added on each side of the benzene molecule,\u201d Wang said. \u201cThis is important in designing new therapeutic drugs.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have found a new method to strategically add deuterium to benzene, an aromatic compound commonly found in crude oil. When applied to the active ingredient of drugs to incorporate deuterium, it could dramatically improve the drugs\u2019 efficacy and safety and even introduce new medicines. To validate the method, which was published in Nature, a [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-108199","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/108199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=108199"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/108199\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=108199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=108199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=108199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}