{"id":106930,"date":"2020-05-11T12:42:18","date_gmt":"2020-05-11T19:42:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/05\/blood-factors-reverse-epigenetic-age"},"modified":"2020-05-11T12:42:18","modified_gmt":"2020-05-11T19:42:18","slug":"blood-factors-reverse-epigenetic-age","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/05\/blood-factors-reverse-epigenetic-age","title":{"rendered":"Blood Factors Reverse Epigenetic Age"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/blood-factors-reverse-epigenetic-age.jpg\"><\/a><\/p>\n<p>Crucially, plasma treatment of the old rats reduced the epigenetic ages of blood, liver and heart by a very large and significant margin, to levels that are comparable with the young rats. According to the six epigenetic clocks, the plasma fraction treatment rejuvenated liver by 73.4%, blood by 52%, heart by 52%, and hypothalamus by 11%. The rejuvenation effects are even more pronounced if we use the final versions of our epigenetic clocks: liver 75%, blood 66%, heart 57%, hypothalamus 19%. According to the final version of the epigenetic clocks, the average rejuvenation across four tissues was 54.2%.<\/p>\n<hr>\n<p>Researchers have demonstrated that epigenetic age can be halved in rats by using signals commonly found in the blood.<\/p>\n<p><strong>Epigenetic changes<\/strong><\/p>\n<p>One of the <a href=\"https:\/\/www.lifespan.io\/aging-explained\/\">proposed reasons we age<\/a> are the changes to gene expression that our cells experience as we get older; these are commonly called <a href=\"https:\/\/www.lifespan.io\/aging-epigenetic-alterations\/\">epigenetic alterations<\/a>. These alterations harm the fundamental functions of our cells and can increase the risk of cancer and other age-related diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Crucially, plasma treatment of the old rats reduced the epigenetic ages of blood, liver and heart by a very large and significant margin, to levels that are comparable with the young rats. According to the six epigenetic clocks, the plasma fraction treatment rejuvenated liver by 73.4%, blood by 52%, heart by 52%, and hypothalamus by [\u2026]<\/p>\n","protected":false},"author":388,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-106930","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/106930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/388"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=106930"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/106930\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=106930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=106930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=106930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}