{"id":106609,"date":"2020-05-05T21:04:02","date_gmt":"2020-05-06T04:04:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/05\/sleep-disorder-sufferers-may-have-help-from-mechanism-regulating-biological-clock"},"modified":"2020-05-05T21:04:02","modified_gmt":"2020-05-06T04:04:02","slug":"sleep-disorder-sufferers-may-have-help-from-mechanism-regulating-biological-clock","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/05\/sleep-disorder-sufferers-may-have-help-from-mechanism-regulating-biological-clock","title":{"rendered":"Sleep disorder sufferers may have help from mechanism regulating biological clock"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/sleep-disorder-sufferers-may-have-help-from-mechanism-regulating-biological-clock2.jpg\"><\/a><\/p>\n<p>Recent sleep surveys show that Singaporeans are among the world\u2019s most sleep-deprived people. Scientists from Duke-NUS Medical School (Duke-NUS) and the University of Tokyo provide new evidence, which supports the presence of a key mechanism that regulates our biological clock. In the study published in <i>PNAS<\/i>, the team used preclinical models to validate that mutations in PER2 protein can alter the balance of the circadian period, which can lead to sleep disorders.<\/p>\n<p>Biological clocks are an organism\u2019s innate timing device. It is composed of specific proteins called clock proteins, which interact in cells throughout the body. Biological clocks produce and regulate <a href=\"https:\/\/medicalxpress.com\/tags\/circadian+rhythms\/\" rel=\"tag\" class=\"\">circadian rhythms <\/a>\u2014the physical, mental, and behavioral changes that follow a daily cycle. Understanding the molecular mechanisms of the circadian clock provides a huge potential to identify therapeutic interventions to mitigate circadian disruption, and its long-term consequences such as diabetes, obesity and cancer among shift workers, who undergo frequent circadian disruption and are more prone to these diseases.<\/p>\n<p>The Duke-NUS scientists had previously discovered that mutations in a specific protein (called casein kinase 1) alters the core clock protein (called PERIOD or PER), and this changes the timing of the <a href=\"https:\/\/medicalxpress.com\/tags\/biological+clock\/\" rel=\"tag\" class=\"\">biological clock<\/a>. In this study, <a href=\"https:\/\/medicalxpress.com\/tags\/preclinical+models\/\" rel=\"tag\" class=\"\">preclinical models<\/a> were used to investigate the role of PER2 (a type of PER protein) in clock regulation to further understand and strengthen the model.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent sleep surveys show that Singaporeans are among the world\u2019s most sleep-deprived people. Scientists from Duke-NUS Medical School (Duke-NUS) and the University of Tokyo provide new evidence, which supports the presence of a key mechanism that regulates our biological clock. In the study published in PNAS, the team used preclinical models to validate that mutations [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-106609","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/106609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=106609"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/106609\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=106609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=106609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=106609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}