{"id":106398,"date":"2020-05-02T12:26:20","date_gmt":"2020-05-02T19:26:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/05\/blood-clotting-patterns-in-lungs-of-covid-19-patients-may-help-explain-apparent-differences-in-mortality"},"modified":"2020-05-02T12:26:20","modified_gmt":"2020-05-02T19:26:20","slug":"blood-clotting-patterns-in-lungs-of-covid-19-patients-may-help-explain-apparent-differences-in-mortality","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/05\/blood-clotting-patterns-in-lungs-of-covid-19-patients-may-help-explain-apparent-differences-in-mortality","title":{"rendered":"Blood Clotting Patterns in Lungs of COVID-19 Patients May Help Explain Apparent Differences in Mortality"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/blood-clotting-patterns-in-lungs-of-covid-19-patients-may-help-explain-apparent-differences-in-mortality2.jpg\"><\/a><\/p>\n<p>The investigators concluded that diffuse bilateral pulmonary inflammation observed in COVID-19 is associated with a novel pulmonary-specific vasculopathy, which is distinct from DIC, and which they\u2019ve termed \u201cpulmonary intravascular coagulopathy (PIC).\u201d<\/p>\n<p>\u201cUnderstanding how these micro-clots are being formed within the lung is critical so that we can develop more effective treatments for our patients, particularly those in high-risk groups,\u201d O\u2019Donnell commented. \u201cFurther studies will be required to investigate whether different blood thinning treatments may have a role in selected high-risk patients in order to reduce the risk of clot formation.\u201d<\/p>\n<p>The authors suggest that larger, controlled studies will be needed to determine whether more intensive anticoagulation and\/or targeted anti-inflammatory therapies might help reduce PIC in patients with severe COVID-19. The findings may also be relevant to growing evidence that some ethnicities are more likely to develop serious COVID-19 than others. \u201cGiven that thrombotic risk is significantly impacted by race, coupled with the accumulating evidence that coagulopathy is important in COVID-19 pathogenesis, our findings raise the intriguing possibility that pulmonary vasculopathy may contribute to the unexplained differences that are beginning to emerge highlighting racial susceptibility to COVID-19 mortality,\u201d they concluded.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The investigators concluded that diffuse bilateral pulmonary inflammation observed in COVID-19 is associated with a novel pulmonary-specific vasculopathy, which is distinct from DIC, and which they\u2019ve termed \u201cpulmonary intravascular coagulopathy (PIC).\u201d \u201cUnderstanding how these micro-clots are being formed within the lung is critical so that we can develop more effective treatments for our patients, particularly [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-106398","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/106398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=106398"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/106398\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=106398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=106398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=106398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}