{"id":106357,"date":"2020-05-01T18:25:37","date_gmt":"2020-05-02T01:25:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/05\/safety-of-aceis-and-arbs-in-patients-with-covid-19-what-is-the-evidence"},"modified":"2020-05-01T18:25:37","modified_gmt":"2020-05-02T01:25:37","slug":"safety-of-aceis-and-arbs-in-patients-with-covid-19-what-is-the-evidence","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/05\/safety-of-aceis-and-arbs-in-patients-with-covid-19-what-is-the-evidence","title":{"rendered":"Safety of ACEIs and ARBs in Patients With COVID-19\u2014What Is the Evidence?"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/logo.safety-of-aceis-and-arbs-in-patients-with-covid-19-what-is-the-evidence.jpg\"><\/a><\/p>\n<p>Coronavirus disease 2019 (COVID-19) is a current pandemic infection caused by a positive-sense RNA virus named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The particularly infectious capacity of the virus, along with mortality rates ranging from 1% to above 5%, has raised concerns across the globe.<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2763803#jvp200063r1\" class=\"\">1<\/a><\/sup> Older patients with comorbid conditions including pulmonary disease, cardiac disease, kidney disease, diabetes, and hypertension have been associated with even higher mortality rates, suggesting particularly susceptible populations.<\/p>\n<p>The increased mortality and morbidity of COVID-19 in patients with hypertension is an association that has been observed in a number of initial epidemiological studies outlining the characteristics of the COVID-19 epidemic in China. Wu et al<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2763803#jvp200063r2\" class=\"\">2<\/a><\/sup> found hypertension to have a hazard ratio of 1.70 for death and 1.82 for acute respiratory distress syndrome in 201 patients with COVID-19. Zhou et al<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2763803#jvp200063r3\" class=\"\">3<\/a><\/sup> found hypertension to have a hazard ratio of 3.05 for in-hospital mortality in 191 patients with COVID-19.<\/p>\n<p>Neither of these studies<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2763803#jvp200063r2\" class=\"\">2<\/a><\/sup><sup>,<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2763803#jvp200063r3\" class=\"\">3<\/a><\/sup> adjusted for confounding variables and thus it remains unclear if this association is related to the pathogenesis of hypertension or another associated comorbidity or treatment. There has been a growing concern that this association with hypertension is confounded by treatment with specific antihypertensive medications: angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Coronavirus disease 2019 (COVID-19) is a current pandemic infection caused by a positive-sense RNA virus named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The particularly infectious capacity of the virus, along with mortality rates ranging from 1% to above 5%, has raised concerns across the globe.1 Older patients with comorbid conditions including pulmonary disease, [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-106357","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/106357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=106357"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/106357\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=106357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=106357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=106357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}