{"id":105913,"date":"2020-04-23T11:44:43","date_gmt":"2020-04-23T18:44:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/04\/reversing-diabetes-with-crispr-and-patient-derived-stem-cells"},"modified":"2020-04-23T11:44:43","modified_gmt":"2020-04-23T18:44:43","slug":"reversing-diabetes-with-crispr-and-patient-derived-stem-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/04\/reversing-diabetes-with-crispr-and-patient-derived-stem-cells","title":{"rendered":"Reversing diabetes with CRISPR and patient-derived stem cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/reversing-diabetes-with-crispr-and-patient-derived-stem-cells2.jpg\"><\/a><\/p>\n<p>Now, scientists at Washington University in St. Louis have developed a way to use gene editing system CRISPR-Cas9 to edit a mutation in human-induced pluripotent stem cells (iPSCs) and then turn them into beta cells. When transplanted into mice, the cells reversed preexisting diabetes in a lasting way, according to results published in the journal <a href=\"https:\/\/stm.sciencemag.org\/lookup\/doi\/10.1126\/scitranslmed.aax9106\">Science Translational Medicine<\/a>.<\/p>\n<p>While the researchers used cells from patients with Wolfram syndrome\u2014a rare childhood diabetes caused by mutations in the WFS1 gene\u2014they argue that the combination of a gene therapy with stem cells could potentially treat other forms of diabetes as well.<\/p>\n<p>Virtual Event<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now, scientists at Washington University in St. Louis have developed a way to use gene editing system CRISPR-Cas9 to edit a mutation in human-induced pluripotent stem cells (iPSCs) and then turn them into beta cells. When transplanted into mice, the cells reversed preexisting diabetes in a lasting way, according to results published in the journal [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-105913","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/105913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=105913"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/105913\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=105913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=105913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=105913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}