{"id":104985,"date":"2020-04-08T23:43:09","date_gmt":"2020-04-09T06:43:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/04\/alzheimers-trial-supports-high-amyloid-levels-as-early-sign-of-disease"},"modified":"2020-04-08T23:43:09","modified_gmt":"2020-04-09T06:43:09","slug":"alzheimers-trial-supports-high-amyloid-levels-as-early-sign-of-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/04\/alzheimers-trial-supports-high-amyloid-levels-as-early-sign-of-disease","title":{"rendered":"Alzheimer\u2019s trial supports high amyloid levels as early sign of disease"},"content":{"rendered":"

<\/a><\/p>\n

An ongoing long-term trial suggests high levels of amyloid proteins in the brain do serve as an early sign of Alzheimer\u2019s disease before cognitive decline becomes apparent.<\/p>\n

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A new study presenting the first data from a long-running US government trial is suggesting high levels of amyloid proteins in the brains of cognitively normal older adults can be an effective presymptomatic sign of early stage Alzheimer\u2019s disease.<\/p>\n

Over the last few decades, the amyloid hypothesis has guided the majority of research into an Alzheimer\u2019s disease treatment. The idea is that a build up of toxic amyloid proteins in the brain, called plaques, is the primary degenerative driver behind the disease.<\/p>\n

Unfortunately a near-constant parade<\/a> of failed clinical trials<\/a> testing anti-amyloid drugs has caused many researchers to begin doubting the amyloid hypothesis<\/a>. From neuroinflammation<\/a> to bacterial infection<\/a>, a broad number of alternative hypotheses<\/a> are currently being investigated, however, some scientists suspect anti-amyloid treatments could still work, as long as they commence before major degenerative symptoms appear.<\/p>\n","protected":false},"excerpt":{"rendered":"

An ongoing long-term trial suggests high levels of amyloid proteins in the brain do serve as an early sign of Alzheimer\u2019s disease before cognitive decline becomes apparent. A new study presenting the first data from a long-running US government trial is suggesting high levels of amyloid proteins in the brains of cognitively normal older adults [\u2026]<\/p>\n","protected":false},"author":461,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1490,47],"tags":[],"class_list":["post-104985","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-government","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/104985","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/461"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=104985"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/104985\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=104985"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=104985"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=104985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}